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Enhancement of MSC adhesion and therapeutic efficiency in ischemic heart using lentivirus delivery with periostin

Authors
 Yun-Hyeong Cho  ;  Min-Ji Cha  ;  Byeong-Wook Song  ;  Il-Kwon Kim  ;  Heesang Song  ;  Woochul Chang  ;  Soyeon Lim  ;  Onju Ham  ;  Se-Yeon Lee  ;  Eunmi Choi  ;  Hyuck Moon Kwon  ;  Ki-Chul Hwang 
Citation
 Biomaterials, Vol.33(5) : 1376-1385, 2012 
Journal Title
 Biomaterials 
ISSN
 0142-9612 
Issue Date
2012
Abstract
Many approaches have shown beneficial effects of modified mesenchymal stem cells (MSCs) for treatment of infarcted myocardium, but have primarily focused on enhancing the survival of transplanted MSCs. Here, we show the dual benefits of periostin-overexpressing MSCs (p-MSCs) for infarcted myocardium. P-MSCs led to the marked histological and functional recovery of infarcted myocardium by enhancing survival of MSCs and directly preventing apoptosis of cardiomyocytes. Survival of p-MSCs themselves and cardiomyocytes co-cultured with p-MSCs or treated with the conditioned media from p-MSCs was significantly increased under hypoxic conditions. Decreases in adhesion-related integrins were reversed in cardiomyocytes co-cultured with p-MSCs, followed by increases in p-PI3K and Akt, indicating that periostin activates the PI3K pathway through adhesion-related integrins. When p-MSCs were injected into myocardial infarcted rats, histological pathology and cardiac function were significantly improved compared to MSC-injected controls. Thus, periostin might be a new target of therapeutic treatments using MSCs as carriers for infarcted myocardium.
Full Text
http://www.sciencedirect.com/science/article/pii/S0142961211013111
DOI
10.1016/j.biomaterials.2011.10.078
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
권혁문(Kwon, Hyuck Moon) ORCID logo https://orcid.org/0000-0001-9901-5015
김일권(Kim, Il Kwon)
송병욱(Song, Byeong Wook)
이세연(Lee, Se Yeon)
임소연(Lim, So Yeon)
장우철(Chang, Woo Chul)
차민지(Cha, Min Ji)
최은미(Choi, Eun Mi)
함온주(Ham, On Ju)
황기철(Hwang, Ki Chul)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89729
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