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Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction

Authors
 Jinkwon Kim  ;  Tae-Jin Song  ;  Ji Hye Park  ;  Hye Sun Lee  ;  Chung Mo Nam  ;  Hyo Suk Nam  ;  Young Dae Kim  ;  Ji Hoe Heo 
Citation
 ATHEROSCLEROSIS, Vol.222(2) : 464-467, 2012 
Journal Title
 ATHEROSCLEROSIS 
ISSN
 0021-9150 
Issue Date
2012
MeSH
Aged ; Cerebral Infarction/blood ; Cerebral Infarction/diagnosis* ; Cerebral Infarction/physiopathology ; Disability Evaluation ; Female ; Humans ; Leukocyte Count* ; Leukocytes* ; Linear Models ; Logistic Models ; Lymphocyte Count ; Lymphocytes ; Male ; Middle Aged ; Multivariate Analysis ; Neutrophils ; Patient Admission ; Predictive Value of Tests ; Prognosis ; Recovery of Function ; Republic of Korea ; Retrospective Studies ; Severity of Illness Index ; Time Factors
Keywords
Leukocyte ; White blood cell ; Lymphocyte ; Stroke
Abstract
OBJECTIVE: We aimed to investigate the relationship of each white blood cells (WBC) subtype with neurologic severity and outcome in acute stroke. METHODS: We included 779 patients with first-ever acute cerebral infarction within 72 h after symptom onset. We investigated the association between counts for WBC subtypes in peripheral blood at admission and (1) initial stroke severity; (2) early change in stroke severity within one week; and (3) functional outcome at three months. RESULTS: Higher total WBC and neutrophil counts were associated with more severe stroke at admission (p<0.001). In contrast, lower lymphocyte counts were associated with a lesser improvement during the first week after admission (p<0.05) and with poor functional outcome at three months (OR=0.706 per 1000 lymphocyte counts/mm(3), p=0.020). CONCLUSIONS: Our study merits further investigation on the role of each WBC subtype in ischemic injury and different prognostic value of WBC subtypes measured at admission in acute stroke.
Full Text
http://www.sciencedirect.com/science/article/pii/S0021915012001566
DOI
22460048
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Kim, Jinkwon(김진권) ORCID logo https://orcid.org/0000-0003-0156-9736
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Park, Ji Hye(박지혜)
Song, Tae Jin(송태진)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89668
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