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Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction

 Jinkwon Kim  ;  Tae-Jin Song  ;  Ji Hye Park  ;  Hye Sun Lee  ;  Chung Mo Nam  ;  Hyo Suk Nam  ;  Young Dae Kim  ;  Ji Hoe Heo 
 ATHEROSCLEROSIS, Vol.222(2) : 464-467, 2012 
Journal Title
Issue Date
Aged ; Cerebral Infarction/blood ; Cerebral Infarction/diagnosis* ; Cerebral Infarction/physiopathology ; Disability Evaluation ; Female ; Humans ; Leukocyte Count* ; Leukocytes* ; Linear Models ; Logistic Models ; Lymphocyte Count ; Lymphocytes ; Male ; Middle Aged ; Multivariate Analysis ; Neutrophils ; Patient Admission ; Predictive Value of Tests ; Prognosis ; Recovery of Function ; Republic of Korea ; Retrospective Studies ; Severity of Illness Index ; Time Factors
Leukocyte ; White blood cell ; Lymphocyte ; Stroke
OBJECTIVE: We aimed to investigate the relationship of each white blood cells (WBC) subtype with neurologic severity and outcome in acute stroke. METHODS: We included 779 patients with first-ever acute cerebral infarction within 72 h after symptom onset. We investigated the association between counts for WBC subtypes in peripheral blood at admission and (1) initial stroke severity; (2) early change in stroke severity within one week; and (3) functional outcome at three months. RESULTS: Higher total WBC and neutrophil counts were associated with more severe stroke at admission (p<0.001). In contrast, lower lymphocyte counts were associated with a lesser improvement during the first week after admission (p<0.05) and with poor functional outcome at three months (OR=0.706 per 1000 lymphocyte counts/mm(3), p=0.020). CONCLUSIONS: Our study merits further investigation on the role of each WBC subtype in ischemic injury and different prognostic value of WBC subtypes measured at admission in acute stroke.
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1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Kim, Jinkwon(김진권) ORCID logo https://orcid.org/0000-0003-0156-9736
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Park, Ji Hye(박지혜)
Song, Tae Jin(송태진)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
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