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Ferritin is independently associated with the presence of coronary artery calcium in 12,033 men

Authors
 Ki-Chul Sung  ;  Seok-Min Kang  ;  Eun-Joo Cho  ;  Jeong Bae Park  ;  Sarah H. Wild  ;  Christopher D. Byrne 
Citation
 ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol.32(10) : 2525-2530, 2012 
Journal Title
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
ISSN
 1079-5642 
Issue Date
2012
MeSH
Adult ; Atherosclerosis/diagnosis ; Atherosclerosis/epidemiology* ; Atherosclerosis/metabolism* ; Biomarkers/metabolism ; Calcium/metabolism* ; Cardiovascular Diseases/epidemiology ; Cohort Studies ; Comorbidity ; Coronary Vessels/metabolism* ; Diabetes Mellitus/blood ; Diabetes Mellitus/epidemiology ; Ferritins/blood* ; Humans ; Incidence ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/epidemiology ; Middle Aged ; Obesity/blood ; Obesity/epidemiology ; Republic of Korea/epidemiology ; Risk Factors
Keywords
atherosclerosis ; cardiometabolic risk factors ; cardiovascular disease ; ferritin ; metabolic syndrome ; transferrin coronary artery calcium score ; type 2 diabetes mellitus
Abstract
OBJECTIVE: Ferritin concentrations are often increased in patients with metabolic syndrome and type 2 diabetes mellitus, but few reports have examined the associations between ferritin and atherosclerosis. We investigated whether any relationship between ferritin and coronary artery calcium score (CACS) >0 (as a marker of atherosclerosis) was independent of potential confounders, such as iron-binding capacity (transferrin), low-grade inflammation, and cardiovascular risk factors.

METHODS AND RESULTS: Data were analyzed from a South Korean occupational cohort of 12 033 men who underwent a cardiac computed tomography estimation of CACS and measurements of multiple cardiovascular risk factors. One-thousand three- hundred-fifteen of 12 033 (11.2%) subjects had a CACS >0. For people with a CACS >0, median (interquartile range) ferritin concentration was 196.8 (136.3-291.9) compared with 182.2 (128.1-253.6) in people with a CACS=0; P<0.001. In the highest ferritin quartile, 14.7% (442/3008) of subjects had a CACS >0 compared with 9.7% (292/3010) in the lowest quartile (P<0.0001). With increasing ferritin quartiles, there were also higher proportions of people with diabetes mellitus (P<0.0001), hypertension (P<0.0001), coronary heart disease (P=0.003), and a Framingham Risk Score >10% (P<0.0001). In logistic regression modeling with CACS >0 as the outcome, ferritin but not transferrin was independently associated with CACS >0 (odds ratio for highest quartile versus lowest quartile, 1.66 [95% CI, 1.3-1.98]; P=0.0001).

CONCLUSIONS: Increased ferritin concentrations are associated with the presence of a marker of early coronary artery atherosclerosis, independently of traditional cardiovascular risk factors including Framingham risk score, transferrin, preexisting vascular disease, diabetes mellitus, metabolic syndrome factors, and low-grade inflammation.
Full Text
http://atvb.ahajournals.org/content/32/10/2525.long
DOI
22837473
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89632
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