Cited 51 times in
Ferritin is independently associated with the presence of coronary artery calcium in 12,033 men
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.date.accessioned | 2014-12-19T16:29:36Z | - |
dc.date.available | 2014-12-19T16:29:36Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1079-5642 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89632 | - |
dc.description.abstract | OBJECTIVE: Ferritin concentrations are often increased in patients with metabolic syndrome and type 2 diabetes mellitus, but few reports have examined the associations between ferritin and atherosclerosis. We investigated whether any relationship between ferritin and coronary artery calcium score (CACS) >0 (as a marker of atherosclerosis) was independent of potential confounders, such as iron-binding capacity (transferrin), low-grade inflammation, and cardiovascular risk factors. METHODS AND RESULTS: Data were analyzed from a South Korean occupational cohort of 12 033 men who underwent a cardiac computed tomography estimation of CACS and measurements of multiple cardiovascular risk factors. One-thousand three- hundred-fifteen of 12 033 (11.2%) subjects had a CACS >0. For people with a CACS >0, median (interquartile range) ferritin concentration was 196.8 (136.3-291.9) compared with 182.2 (128.1-253.6) in people with a CACS=0; P<0.001. In the highest ferritin quartile, 14.7% (442/3008) of subjects had a CACS >0 compared with 9.7% (292/3010) in the lowest quartile (P<0.0001). With increasing ferritin quartiles, there were also higher proportions of people with diabetes mellitus (P<0.0001), hypertension (P<0.0001), coronary heart disease (P=0.003), and a Framingham Risk Score >10% (P<0.0001). In logistic regression modeling with CACS >0 as the outcome, ferritin but not transferrin was independently associated with CACS >0 (odds ratio for highest quartile versus lowest quartile, 1.66 [95% CI, 1.3-1.98]; P=0.0001). CONCLUSIONS: Increased ferritin concentrations are associated with the presence of a marker of early coronary artery atherosclerosis, independently of traditional cardiovascular risk factors including Framingham risk score, transferrin, preexisting vascular disease, diabetes mellitus, metabolic syndrome factors, and low-grade inflammation. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Atherosclerosis/diagnosis | - |
dc.subject.MESH | Atherosclerosis/epidemiology* | - |
dc.subject.MESH | Atherosclerosis/metabolism* | - |
dc.subject.MESH | Biomarkers/metabolism | - |
dc.subject.MESH | Calcium/metabolism* | - |
dc.subject.MESH | Cardiovascular Diseases/epidemiology | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Coronary Vessels/metabolism* | - |
dc.subject.MESH | Diabetes Mellitus/blood | - |
dc.subject.MESH | Diabetes Mellitus/epidemiology | - |
dc.subject.MESH | Ferritins/blood* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolic Syndrome/blood | - |
dc.subject.MESH | Metabolic Syndrome/epidemiology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Obesity/blood | - |
dc.subject.MESH | Obesity/epidemiology | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Ferritin is independently associated with the presence of coronary artery calcium in 12,033 men | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ki-Chul Sung | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Eun-Joo Cho | - |
dc.contributor.googleauthor | Jeong Bae Park | - |
dc.contributor.googleauthor | Sarah H. Wild | - |
dc.contributor.googleauthor | Christopher D. Byrne | - |
dc.identifier.doi | 10.1161/ATVBAHA.112.253088 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00037 | - |
dc.relation.journalcode | J00238 | - |
dc.identifier.eissn | 1524-4636 | - |
dc.identifier.pmid | 22837473 | - |
dc.identifier.url | http://atvb.ahajournals.org/content/32/10/2525.long | - |
dc.subject.keyword | atherosclerosis | - |
dc.subject.keyword | cardiometabolic risk factors | - |
dc.subject.keyword | cardiovascular disease | - |
dc.subject.keyword | ferritin | - |
dc.subject.keyword | metabolic syndrome | - |
dc.subject.keyword | transferrin coronary artery calcium score | - |
dc.subject.keyword | type 2 diabetes mellitus | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | Kang, Seok Min | - |
dc.citation.volume | 32 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2525 | - |
dc.citation.endPage | 2530 | - |
dc.identifier.bibliographicCitation | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol.32(10) : 2525-2530, 2012 | - |
dc.identifier.rimsid | 32365 | - |
dc.type.rims | ART | - |
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