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Ferritin is independently associated with the presence of coronary artery calcium in 12,033 men

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dc.contributor.author강석민-
dc.date.accessioned2014-12-19T16:29:36Z-
dc.date.available2014-12-19T16:29:36Z-
dc.date.issued2012-
dc.identifier.issn1079-5642-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89632-
dc.description.abstractOBJECTIVE: Ferritin concentrations are often increased in patients with metabolic syndrome and type 2 diabetes mellitus, but few reports have examined the associations between ferritin and atherosclerosis. We investigated whether any relationship between ferritin and coronary artery calcium score (CACS) >0 (as a marker of atherosclerosis) was independent of potential confounders, such as iron-binding capacity (transferrin), low-grade inflammation, and cardiovascular risk factors. METHODS AND RESULTS: Data were analyzed from a South Korean occupational cohort of 12 033 men who underwent a cardiac computed tomography estimation of CACS and measurements of multiple cardiovascular risk factors. One-thousand three- hundred-fifteen of 12 033 (11.2%) subjects had a CACS >0. For people with a CACS >0, median (interquartile range) ferritin concentration was 196.8 (136.3-291.9) compared with 182.2 (128.1-253.6) in people with a CACS=0; P<0.001. In the highest ferritin quartile, 14.7% (442/3008) of subjects had a CACS >0 compared with 9.7% (292/3010) in the lowest quartile (P<0.0001). With increasing ferritin quartiles, there were also higher proportions of people with diabetes mellitus (P<0.0001), hypertension (P<0.0001), coronary heart disease (P=0.003), and a Framingham Risk Score >10% (P<0.0001). In logistic regression modeling with CACS >0 as the outcome, ferritin but not transferrin was independently associated with CACS >0 (odds ratio for highest quartile versus lowest quartile, 1.66 [95% CI, 1.3-1.98]; P=0.0001). CONCLUSIONS: Increased ferritin concentrations are associated with the presence of a marker of early coronary artery atherosclerosis, independently of traditional cardiovascular risk factors including Framingham risk score, transferrin, preexisting vascular disease, diabetes mellitus, metabolic syndrome factors, and low-grade inflammation.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAtherosclerosis/diagnosis-
dc.subject.MESHAtherosclerosis/epidemiology*-
dc.subject.MESHAtherosclerosis/metabolism*-
dc.subject.MESHBiomarkers/metabolism-
dc.subject.MESHCalcium/metabolism*-
dc.subject.MESHCardiovascular Diseases/epidemiology-
dc.subject.MESHCohort Studies-
dc.subject.MESHComorbidity-
dc.subject.MESHCoronary Vessels/metabolism*-
dc.subject.MESHDiabetes Mellitus/blood-
dc.subject.MESHDiabetes Mellitus/epidemiology-
dc.subject.MESHFerritins/blood*-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Syndrome/blood-
dc.subject.MESHMetabolic Syndrome/epidemiology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHObesity/blood-
dc.subject.MESHObesity/epidemiology-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.titleFerritin is independently associated with the presence of coronary artery calcium in 12,033 men-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorKi-Chul Sung-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorEun-Joo Cho-
dc.contributor.googleauthorJeong Bae Park-
dc.contributor.googleauthorSarah H. Wild-
dc.contributor.googleauthorChristopher D. Byrne-
dc.identifier.doi22837473-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00037-
dc.relation.journalcodeJ00238-
dc.identifier.eissn1524-4636-
dc.identifier.pmid22837473-
dc.identifier.urlhttp://atvb.ahajournals.org/content/32/10/2525.long-
dc.subject.keywordatherosclerosis-
dc.subject.keywordcardiometabolic risk factors-
dc.subject.keywordcardiovascular disease-
dc.subject.keywordferritin-
dc.subject.keywordmetabolic syndrome-
dc.subject.keywordtransferrin coronary artery calcium score-
dc.subject.keywordtype 2 diabetes mellitus-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.citation.volume32-
dc.citation.number10-
dc.citation.startPage2525-
dc.citation.endPage2530-
dc.identifier.bibliographicCitationARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol.32(10) : 2525-2530, 2012-
dc.identifier.rimsid32365-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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