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Mean platelet volume (MPV) is associated with leukoaraiosis in the apparently healthy elderly

Authors
 Seong-Jin Kang  ;  Byoung-Jin Park  ;  Jae-Yong Shim  ;  Hye-Ree Lee  ;  Ji-Man Hong  ;  Yong-Jae Lee 
Citation
 ARCHIVES OF GERONTOLOGY AND GERIATRICS, Vol.54(2) : 118-121, 2012 
Journal Title
 ARCHIVES OF GERONTOLOGY AND GERIATRICS 
ISSN
 0167-4943 
Issue Date
2012
MeSH
Age Factors ; Aged ; Blood Platelets/pathology* ; Brain/pathology ; Female ; Hematologic Tests ; Humans ; Leukoaraiosis/blood* ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroimaging ; Sex Factors
Keywords
Age Factors ; Aged ; Blood Platelets/pathology* ; Brain/pathology ; Female ; Hematologic Tests ; Humans ; Leukoaraiosis/blood* ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroimaging ; Sex Factors
Abstract
Leukoaraiosis refers to diffuse white matter abnormalities on MR brain scans, which have been suggested to be associated with cerebral microangiopathy and geriatric syndromes such as cognitive impairment, depressive mood and gait disturbance. MPV is a simple indicator of platelet size and has been known to be a marker of platelet activity. MPV is now considered a link between inflammation and thrombosis in multiple cardiovascular and cerebrovascular disorders including hypertension, peripheral artery disease, and stroke. This cross-sectional study aims to evaluate the association between MPV and leukoaraiosis for 223 healthy elderly subjects (142 men, 81 women; mean age 66.0±5.2 years) in a health examination program including brain magnetic resonance imaging (MRI) scans. The overall prevalence rate of leukoaraiosis was 15.3%. The mean MPV was significantly higher in the leukoaraiosis group than control group: 8.4±0.8 and 8.1±1.0, respectively (p=0.036). A higher value of MPV was independently associated with an increased risk of leukoaraiosis. In the multivariate logistic analysis, the odds ratio (OR) (95% confidence interval (CI)) for leukoaraiosis was 1.61 (1.02-2.53) with 1 fL of MPV increment after adjusting for confounding variables. In conclusion, MPV was found to be independently and positively associated with leukoaraiosis. This finding indicates that MPV values may be a useful additional measure in assessing the risk of leukoaraiosis in the clinical setting.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167494311003050
DOI
22079338
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Park, Byoung Jin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Ree(이혜리)
Hong, Ji Man(홍지만) ORCID logo https://orcid.org/0000-0002-0696-8448
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89612
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