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Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride

Authors
 Jae Yong Choi  ;  Chul Hoon Kim  ;  Tae Joo Jeon  ;  Won Gil Cho  ;  Jin Suk Lee  ;  Soo Jin Lee  ;  Tae Hyun Choi  ;  Byoung Soo Kim  ;  Chi Hoon Yi  ;  Youngbeom Seo  ;  Dae Ik Yi  ;  Sang Jin Han  ;  Minkyung Lee  ;  Dong Goo Kim  ;  Jong Doo Lee  ;  Gwangil An  ;  Young Hoon Ryu 
Citation
 APPLIED RADIATION AND ISOTOPES, Vol.70(12) : 2689-2694, 2012 
Journal Title
 APPLIED RADIATION AND ISOTOPES 
ISSN
 0969-8043 
Issue Date
2012
MeSH
Animals ; Benzamides* ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism ; Dopamine Plasma Membrane Transport Proteins/metabolism* ; Down-Regulation ; Fluorine Radioisotopes* ; Male ; Oxidopamine ; Parkinsonian Disorders/chemically induced ; Parkinsonian Disorders/physiopathology* ; Positron-Emission Tomography/methods ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D2/metabolism* ; Tomography, Emission-Computed, Single-Photon ; Tropanes* ; Up-Regulation
Keywords
Animals ; Benzamides* ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism ; Dopamine Plasma Membrane Transport Proteins/metabolism* ; Down-Regulation ; Fluorine Radioisotopes* ; Male ; Oxidopamine ; Parkinsonian Disorders/chemically induced ; Parkinsonian Disorders/physiopathology* ; Positron-Emission Tomography/methods ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D2/metabolism* ; Tomography, Emission-Computed, Single-Photon ; Tropanes* ; Up-Regulation
Abstract
The aim of this study was to investigate dopaminergic function in unilaterally lesioned 6-OHDA rats by dual PET radioligands: [(18)F]FPCIT (a dopamine transporter imaging radioligand) and [(18)F]fallypride (a dopamine D2 receptors imaging radioligand). As a result, the brain uptake of [(18)F]FPCIT was significantly reduced and that of [(18)F]fallypride was increased in the ipsilateral striatum (lesion side) of the 6-OHDA rats. These findings implicated that dopamine transporter is down-regulated and dopamine D2 receptor is up-regulated in this hemiparkinsonian rat model.
Full Text
http://www.sciencedirect.com/science/article/pii/S0969804312004605
DOI
23041777
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Goo(김동구)
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Min Kyung(이민경)
Lee, Jong Doo(이종두)
Jeon, Tae Joo(전태주) ORCID logo https://orcid.org/0000-0002-7574-6734
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89599
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