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Nuclear expression of Yes-associated protein 1 correlates with poor prognosis in intestinal type gastric cancer

Authors
 MEIYING SONG  ;  JAE-HO CHEONG  ;  HOGUEN KIM  ;  SUNG HOON NOH  ;  HYUNKI KIM 
Citation
 ANTICANCER RESEARCH, Vol.32(9) : 3827-3834, 2012 
Journal Title
 ANTICANCER RESEARCH 
ISSN
 0250-7005 
Issue Date
2012
MeSH
Adaptor Proteins, Signal Transducing/biosynthesis* ; Aged ; Biomarkers, Tumor/biosynthesis* ; Cell Nucleus/metabolism ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Staging ; Phosphoproteins/biosynthesis* ; Prognosis ; Stomach Neoplasms/metabolism* ; Stomach Neoplasms/pathology
Keywords
Cisplatin, chemoradiotherapy, etoposide, induction drug therapy, irinotecan, non-small cell lung neoplasms
Abstract
BACKGROUND: Yes-associated protein 1 (YAP1) is an effector of the Hippo pathway, which is critical for regulating organ size and cell proliferation in mammals. To investigate the prognostic value of YAP1 in gastric cancer (GC), we assessed its expression in tumors from patients. MATERIALS AND METHODS: We examined the nuclear expression of the YAP1 protein in 223 cases of GC, particularly of stage II and III disease, using immunohistochemistry. RESULTS: Positive nuclear expression of YAP1 was detected in 27.4% (61/223) of total GCs, 29.1% (34/117) of the intestinal-type GCs (IGC) and 25.5% (27/106) of the diffuse-type GCs (DGC). In the IGC group, we found that the overall survival rate among patients with YAP1 nuclear expression-positive tumors was lower than that in the expression-negative group (p=0.021). Cox multivariate analysis revealed that the nuclear expression of YAP1 was an independent prognosticator of IGC (p=0.018). CONCLUSION: The nuclear overexpression of YAP1 is an independent biomarker for poor survival, especially for patients with intestinal-type gastric cancer.
Full Text
http://ar.iiarjournals.org/content/32/9/3827.long
DOI
22993325
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Kim, Ho Keun(김호근)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Song, Mei Ying(송미영)
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89573
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