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Nuclear expression of Yes-associated protein 1 correlates with poor prognosis in intestinal type gastric cancer

DC Field Value Language
dc.contributor.author김현기-
dc.contributor.author김호근-
dc.contributor.author노성훈-
dc.contributor.author송미영-
dc.contributor.author정재호-
dc.date.accessioned2014-12-19T16:27:46Z-
dc.date.available2014-12-19T16:27:46Z-
dc.date.issued2012-
dc.identifier.issn0250-7005-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89573-
dc.description.abstractBACKGROUND: Yes-associated protein 1 (YAP1) is an effector of the Hippo pathway, which is critical for regulating organ size and cell proliferation in mammals. To investigate the prognostic value of YAP1 in gastric cancer (GC), we assessed its expression in tumors from patients. MATERIALS AND METHODS: We examined the nuclear expression of the YAP1 protein in 223 cases of GC, particularly of stage II and III disease, using immunohistochemistry. RESULTS: Positive nuclear expression of YAP1 was detected in 27.4% (61/223) of total GCs, 29.1% (34/117) of the intestinal-type GCs (IGC) and 25.5% (27/106) of the diffuse-type GCs (DGC). In the IGC group, we found that the overall survival rate among patients with YAP1 nuclear expression-positive tumors was lower than that in the expression-negative group (p=0.021). Cox multivariate analysis revealed that the nuclear expression of YAP1 was an independent prognosticator of IGC (p=0.018). CONCLUSION: The nuclear overexpression of YAP1 is an independent biomarker for poor survival, especially for patients with intestinal-type gastric cancer.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfANTICANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdaptor Proteins, Signal Transducing/biosynthesis*-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor/biosynthesis*-
dc.subject.MESHCell Nucleus/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPhosphoproteins/biosynthesis*-
dc.subject.MESHPrognosis-
dc.subject.MESHStomach Neoplasms/metabolism*-
dc.subject.MESHStomach Neoplasms/pathology-
dc.titleNuclear expression of Yes-associated protein 1 correlates with poor prognosis in intestinal type gastric cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorMEIYING SONG-
dc.contributor.googleauthorJAE-HO CHEONG-
dc.contributor.googleauthorHOGUEN KIM-
dc.contributor.googleauthorSUNG HOON NOH-
dc.contributor.googleauthorHYUNKI KIM-
dc.identifier.doi22993325-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01108-
dc.contributor.localIdA01183-
dc.contributor.localIdA01281-
dc.contributor.localIdA02021-
dc.contributor.localIdA03717-
dc.relation.journalcodeJ00188-
dc.identifier.eissn1791-7530-
dc.identifier.pmid22993325-
dc.identifier.urlhttp://ar.iiarjournals.org/content/32/9/3827.long-
dc.subject.keywordCisplatin, chemoradiotherapy, etoposide, induction drug therapy, irinotecan, non-small cell lung neoplasms-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameSong, Mei Ying-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorSong, Mei Ying-
dc.contributor.affiliatedAuthorCheong, Jae Ho-
dc.citation.volume32-
dc.citation.number9-
dc.citation.startPage3827-
dc.citation.endPage3834-
dc.identifier.bibliographicCitationANTICANCER RESEARCH, Vol.32(9) : 3827-3834, 2012-
dc.identifier.rimsid32323-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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