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Clinical implication of elastography as a prognostic factor of papillary thyroid microcarcinoma

Authors
 Moon, Hee Jung  ;  Kim, Eun-Kyung  ;  Yoon, Jung Hyun  ;  Kwak, Jin Young 
Citation
 ANNALS OF SURGICAL ONCOLOGY, Vol.19(7) : 2279-2287, 2012 
Journal Title
 ANNALS OF SURGICAL ONCOLOGY 
ISSN
 1068-9265 
Issue Date
2012
MeSH
Adolescent ; Adult ; Aged ; Carcinoma, Papillary/diagnostic imaging ; Carcinoma, Papillary/secondary* ; Carcinoma, Papillary/surgery ; Child ; Elasticity Imaging Techniques* ; Female ; Follow-Up Studies ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology* ; Thyroid Neoplasms/surgery ; Young Adult
Keywords
Lymph Node Metastasis ; Papillary Thyroid Carcinoma ; Lateral Compartment ; Extrathyroidal Extension ; Lateral Lymph Node Metastasis
Abstract
BACKGROUND: A firm and hard thyroid nodule on palpation is known to be associated with an increased risk of thyroid malignancy. Elastography has been introduced to evaluate the tissue hardness objectively. We investigated the clinical implications of elastography as a prognostic factor in patients with papillary thyroid microcarcinoma. METHODS: Elastography images were classified according to Rago scores of 1-5. Malignancies with Rago scores of 4 or 5 were considered as "hard" and remaining malignancies as "soft." Clinicopathologic characteristics were compared between patients with hard or soft malignancies according to the extrathyroidal extension and central and lateral lymph node metastasis by using chi-square tests, Fisher's exact test, and independent t tests. Odds ratios with 95% confidence intervals were calculated for evaluating the factors for predicting extrathyroidal extension and central and lateral lymph node metastasis. RESULTS: A hard malignancy on the Rago score was significantly associated with pathologic extrathyroidal extension compared with a soft malignancy (P=0.001). The odds ratio of a hard malignancy on the Rago score for predicting extrathyroidal extension was 5.060 (95% confidence interval, 1.565-16.358). A hard malignancy on Rago scores was not associated with central or lateral lymph node metastasis. CONCLUSIONS: A hard malignancy on the Rago score of elastography was an independent factor for predicting pathologic extrathyroidal extension on pathology.
Full Text
http://link.springer.com/article/10.1245%2Fs10434-011-2212-3
DOI
22246427
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89551
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