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Enhancement patterns of hepatocellular carcinoma after transarterial chemoembolization using drug-eluting beads on arterial phase CT images: a pilot retrospective study

 Woo-Suk Chung  ;  Kwang-Hun Lee  ;  Mi-Suk Park  ;  Yeo Jin Lee  ;  Joonho Kwon  ;  Song-Ee Baek  ;  Myeong-Jin Kim 
 AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.199(2) : 349-359, 2012 
Journal Title
Issue Date
Adult ; Aged ; Antibiotics, Antineoplastic/administration & dosage* ; Carcinoma, Hepatocellular/diagnostic imaging* ; Carcinoma, Hepatocellular/drug therapy* ; Chemoembolization, Therapeutic/methods* ; Chi-Square Distribution ; Contrast Media ; Disease Progression ; Doxorubicin/administration & dosage* ; Female ; Humans ; Iohexol/analogs & derivatives ; Liver Neoplasms/diagnostic imaging* ; Liver Neoplasms/drug therapy* ; Male ; Microspheres* ; Middle Aged ; Pilot Projects ; Radiographic Image Interpretation, Computer-Assisted ; Retrospective Studies ; Survival Rate ; Tomography, X-Ray Computed/methods* ; Treatment Outcome
CT ; doxorubicin ; drug-eluting beads ; hepatocellular carcinoma ; transarterial chemoembolization
OBJECTIVE: The purpose of this article is to assess CT enhancement patterns of hepatocellular carcinoma (HCC) within 1 month after transarterial chemoembolization (TACE) using drug-eluting beads and to determine whether enhancement patterns may be useful for predicting local tumor progression. MATERIALS AND METHODS: Forty-one patients with 50 HCCs underwent CT within 1 month after TACE with drug-eluting beads. Two blinded readers independently reviewed the arterial phase images and classified enhancement patterns as follows: no enhancement, peripheral ring enhancement, and peripheral nodulelike enhancement. Enhancement patterns were correlated with time to tumor progression of enhancing tissue by log-rank test. RESULTS: In the group with no enhancement, 92.3% (24/26) had not progressed and 7.7% (2/26) showed progression; for peripheral ring enhancement, 83.3% (10/12) had not progressed and 16.7% (2/12) showed progression; and for peripheral nodulelike enhancement, 16.7% (2/12) had not progressed and 83.3% (10/12) showed progression. The time to progression of enhancing tissue was significantly different between the group with no enhancement plus peripheral ring enhancement and the group with peripheral nodulelike enhancement (p < 0.001). CONCLUSION: Analysis of enhancement patterns at the arterial phase of the first follow-up CT after TACE with drug-eluting beads is helpful for predicting progression of treated HCC.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Joon Ho(권준호) ORCID logo https://orcid.org/0000-0002-6178-7252
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Baek, Song Ee(백송이) ORCID logo https://orcid.org/0000-0001-8146-2570
Lee, Yeo Jin(이여진)
Chung, Woo Seok(정우석)
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