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CT angiography of the renal arteries: comparison of lower-tube-voltage CTA with moderate-concentration iodinated contrast material and conventional CTA

 Eun-Suk Cho  ;  Jeong-Sik Yu  ;  Jhii-Hyun Ahn  ;  Joo Hee Kim  ;  Jae-Joon Chung  ;  Hyeon-Kyeong Lee  ;  Kyung Hee Lee Read More: http://www.ajronline.org/doi/abs/ . /AJR. . 
 AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.199(1) : 96-102, 2012 
Journal Title
Issue Date
Adult ; Angiography/methods* ; Contrast Media ; Dose-Response Relationship ; Drug ; Feasibility Studies ; Female ; Humans ; Iodine/administration & dosage ; Male ; Phantoms ; Imaging ; Radiographic Image Enhancement/methods* ; Reference Values ; Renal Artery/diagnostic imaging* ; Tomography ; X-Ray Computed* ; Young Adult
angiography ; contrast media ; CT angiography ; radiation ; renal artery ; renovascular hypertension
OBJECTIVE: The objective of our study was to investigate the feasibility of an 80-kVp protocol using a moderate-concentration contrast medium (CM) for CT angiography of the renal arteries by comparison with a conventional 120-kVp protocol using a high-concentration CM.

SUBJECTS AND METHODS: Attenuation values and signal-to-noise ratios (SNRs) were determined in a phantom for the 120-kVp protocol with a high-concentration CM and the 80-kVp protocol with a moderate-concentration CM. In addition, 50 patients were prospectively enrolled in the study: 25 were scanned with 120 kVp and 200 effective mAs (mAs(eff)) after the administration of 110 mL of high-concentration CM (370 mg I/mL), and the other 25 were scanned with 80 kVp and 585 mAs(eff) after the administration of 110 mL of moderate-concentration CM (300 mg I/mL). Images of the two groups were compared in terms of arterial attenuation, SNR, contrast-to-noise ratio (CNR), and subjective degree of arterial enhancement and image quality.

RESULTS: The mean attenuation of the main renal artery was significantly higher (p < 0.001) in the 80-kVp group who received moderate-concentration CM (mean ± SD, 370.0 ± 65.0 HU) than in the 120-kVp group who received high-concentration CM (269.9 ± 27.8 HU) without significant differences in SNR and CNR values. The 80-kVp protocol had significantly higher quality scores for arterial enhancement, sharpness of the artery, and overall diagnostic quality compared with the 120-kVp protocol. The effective dose of the 80-kVp protocol (4.5 mSv) was 8.2% lower than that of the 120-kVp protocol (4.9 mSv).

CONCLUSION: The use of 80 kVp with moderate-concentration CM could improve arterial enhancement and provide superior image quality with a smaller amount of iodine and a lower radiation dose.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hee(김주희) ORCID logo https://orcid.org/0000-0001-5383-3602
Ahn, Jhii Hyun(안지현)
Yu, Jeong Sik(유정식) ORCID logo https://orcid.org/0000-0002-8171-5838
Chung, Jae Joon(정재준) ORCID logo https://orcid.org/0000-0002-7447-1193
Cho, Eun Suk(조은석)
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