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Structural and functional predictors of visual outcome of epiretinal membrane surgery.

Authors
 Ji Hyun Kim  ;  Yong Min Kim  ;  Eun Jee Chung  ;  Soo Young Lee  ;  Hyoung Jun Koh 
Citation
 AMERICAN JOURNAL OF OPHTHALMOLOGY, Vol.153(1) : 103-110, 2012 
Journal Title
 AMERICAN JOURNAL OF OPHTHALMOLOGY 
ISSN
 0002-9394 
Issue Date
2012
MeSH
Adolescent ; Adult ; Aged ; Area Under Curve ; Electroretinography ; Epiretinal Membrane/physiopathology ; Epiretinal Membrane/surgery* ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; ROC Curve ; Retina/physiology* ; Retrospective Studies ; Tomography, Optical Coherence ; Treatment Outcome ; Visual Acuity/physiology* ; Vitrectomy*
Keywords
Adolescent ; Adult ; Aged ; Area Under Curve ; Electroretinography ; Epiretinal Membrane/physiopathology ; Epiretinal Membrane/surgery* ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; ROC Curve ; Retina/physiology* ; Retrospective Studies ; Tomography, Optical Coherence ; Treatment Outcome ; Visual Acuity/physiology* ; Vitrectomy*
Abstract
PURPOSE: To evaluate the utility of preoperative optical coherence tomography (OCT) and multifocal electroretinography (mfERG) in prediction of visual outcomes after idiopathic epiretinal membrane (ERM) surgery. DESIGN: Retrospective, observational case series. METHODS: One hundred eyes of 100 patients with idiopathic unilateral ERM who underwent vitrectomy for ERM removal were retrospectively reviewed. Correlations between preoperative data (OCT and mfERG) and final best-corrected visual acuity (BCVA) were investigated using Pearson correlation analysis. One-way analysis of variance (ANOVA) was used to determine whether final BCVA and mfERG values differed among subgroups varying in photoreceptor integrity status. Receiver operating characteristic (ROC) curve analysis was performed to obtain a cutoff value of the P1 implicit time predicting visual recovery (final BCVA ≥20/25). RESULTS: BCVA significantly improved, and 65 of 84 eyes (77%) achieved visual recovery of more than 2 Snellen lines after ERM surgery. Final BCVA was significantly correlated with preoperative photoreceptor integrity and P1 implicit time. The area under the ROC (AUROC) curve was statistically significant when P1 implicit time was examined, and the cutoff value for good visual prognosis was 40.81 msec (sensitivity: 72.7%; specificity: 81.3%). CONCLUSION: Photoreceptor disruption detected by OCT and P1 implicit time delay on mfERG were significant predictors of poor visual recovery after ERM surgery.
Full Text
http://www.sciencedirect.com/science/article/pii/S0002939411005484
DOI
21937015
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Kim, Yong Min(김용민)
Kim, Ji Hyun(김지현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89426
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