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Primary thyroid marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type: Clinical manifestation and outcome of a rare disease - Consortium for improving survival of lymphoma study

Authors
 Oh S.Y.  ;  Kim W.S.  ;  Kim J.S.  ;  Kim S.J.  ;  Lee S.  ;  Lee D.H.  ;  Kang H.J.  ;  Song M.K.  ;  Kim H.J.  ;  Kwon J.H.  ;  Kwak J.-Y.  ;  Park B.-B.  ;  Do Y.-R.  ;  Jeong S.H.  ;  Suh C. 
Citation
 ACTA HAEMATOLOGICA, Vol.127(2) : 100-104, 2012 
Journal Title
ACTA HAEMATOLOGICA
ISSN
 0001-5792 
Issue Date
2012
MeSH
Adult ; Aged ; Aged, 80 and over ; Combined Modality Therapy ; Female ; Humans ; Lymphoma, B-Cell, Marginal Zone/pathology* ; Lymphoma, B-Cell, Marginal Zone/therapy ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Thyroid Neoplasms/pathology* ; Thyroid Neoplasms/therapy ; Treatment Outcome
Keywords
B-cell lymphoma ; Marginal zone ; Thyroid
Abstract
Purpose: Primary thyroid marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type (pTY-MZL) is an extremely uncommon form of lymphoma. Due to its rarity, the natural history and optimal treatment modality for this disease have yet to be clearly established. Methods: A total of 27 patients with histologically confirmed pTY-MZL were retrospectively analyzed. Results: The median age of our subjects was 53 years (range 25–82). This study involved 17 females (63.0%) and 10 males (37.0%). Twenty-four out of 27 patients (88.9%) initially presented with localized disease, defined by Ann Arbor stage I/II. Bone marrow involvement was detected in 8.3% of the patients (2 patients), and 91.7% of the patients (25 of 27) were categorized into the low or low-intermediate risk group, according to the International Prognostic Index criteria. Accompanying Hashimoto’s thyroiditis was detected in 72% of the patients, whereas thyroglobulin antibody levels were elevated in 70% of the patients. Twenty-six patients were treated with surgery, radiotherapy or chemotherapy, and 25 patients achieved complete remission. During the follow-up period, only 2 patients evidenced progression, and no deaths occurred over the course of the study. Conclusion: pTY-MZL tends to be an indolent disease. However, unlike other mucosa-associated lymphoid tissue site MZLs, pTY-MZL was well controlled via several treatment modalities, and the patients’ responses were sustained for a prolonged period.
Full Text
http://www.karger.com/Article/FullText/333113
DOI
22178776
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89364
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