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Primary thyroid marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type: Clinical manifestation and outcome of a rare disease - Consortium for improving survival of lymphoma study
DC Field | Value | Language |
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dc.contributor.author | 김진석 | - |
dc.date.accessioned | 2014-12-19T16:21:07Z | - |
dc.date.available | 2014-12-19T16:21:07Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0001-5792 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89364 | - |
dc.description.abstract | Purpose: Primary thyroid marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type (pTY-MZL) is an extremely uncommon form of lymphoma. Due to its rarity, the natural history and optimal treatment modality for this disease have yet to be clearly established. Methods: A total of 27 patients with histologically confirmed pTY-MZL were retrospectively analyzed. Results: The median age of our subjects was 53 years (range 25–82). This study involved 17 females (63.0%) and 10 males (37.0%). Twenty-four out of 27 patients (88.9%) initially presented with localized disease, defined by Ann Arbor stage I/II. Bone marrow involvement was detected in 8.3% of the patients (2 patients), and 91.7% of the patients (25 of 27) were categorized into the low or low-intermediate risk group, according to the International Prognostic Index criteria. Accompanying Hashimoto’s thyroiditis was detected in 72% of the patients, whereas thyroglobulin antibody levels were elevated in 70% of the patients. Twenty-six patients were treated with surgery, radiotherapy or chemotherapy, and 25 patients achieved complete remission. During the follow-up period, only 2 patients evidenced progression, and no deaths occurred over the course of the study. Conclusion: pTY-MZL tends to be an indolent disease. However, unlike other mucosa-associated lymphoid tissue site MZLs, pTY-MZL was well controlled via several treatment modalities, and the patients’ responses were sustained for a prolonged period. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ACTA HAEMATOLOGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphoma, B-Cell, Marginal Zone/pathology* | - |
dc.subject.MESH | Lymphoma, B-Cell, Marginal Zone/therapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Thyroid Neoplasms/pathology* | - |
dc.subject.MESH | Thyroid Neoplasms/therapy | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Primary thyroid marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type: Clinical manifestation and outcome of a rare disease - Consortium for improving survival of lymphoma study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Oh S.Y. | - |
dc.contributor.googleauthor | Kim W.S. | - |
dc.contributor.googleauthor | Kim J.S. | - |
dc.contributor.googleauthor | Kim S.J. | - |
dc.contributor.googleauthor | Lee S. | - |
dc.contributor.googleauthor | Lee D.H. | - |
dc.contributor.googleauthor | Kang H.J. | - |
dc.contributor.googleauthor | Song M.K. | - |
dc.contributor.googleauthor | Kim H.J. | - |
dc.contributor.googleauthor | Kwon J.H. | - |
dc.contributor.googleauthor | Kwak J.-Y. | - |
dc.contributor.googleauthor | Park B.-B. | - |
dc.contributor.googleauthor | Do Y.-R. | - |
dc.contributor.googleauthor | Jeong S.H. | - |
dc.contributor.googleauthor | Suh C. | - |
dc.identifier.doi | 10.1159/000333113 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01017 | - |
dc.relation.journalcode | J00014 | - |
dc.identifier.eissn | 1421-9662 | - |
dc.identifier.pmid | 22178776 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/333113 | - |
dc.subject.keyword | B-cell lymphoma | - |
dc.subject.keyword | Marginal zone | - |
dc.subject.keyword | Thyroid | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.citation.volume | 127 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 100 | - |
dc.citation.endPage | 104 | - |
dc.identifier.bibliographicCitation | ACTA HAEMATOLOGICA, Vol.127(2) : 100-104, 2012 | - |
dc.identifier.rimsid | 34590 | - |
dc.type.rims | ART | - |
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