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일 대학병원 정신증 환자에서 항정신병약물 병용요법의 사용

Other Titles
 Antipsychotic Polypharmacy in the Treatment of Patients with Related Psychoses at a University Hospital 
 장진구  ;  노대영  ;  안석균  ;  조현상  ;  김찬형 
 Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.24(2) : 69-75, 2013 
Journal Title
 Korean Journal of Psychopharmacology (대한정신약물학회지) 
Issue Date
Psychosis ; Antipsychotics ; Polypharmacy ; Combination
Objective The practice of antipsychotic polypharmacy is common, despite lack of supporting evidence. The aims of this study were to estimate the prevalence of antipsychotic polypharmacy in a psychiatric university hospital in Korea and find out the clinical factors associated with antipsychotic polypharmacy. Methods We reviewed medical records of the patients discharged from Severance Mental Health Hospital (SMH) for the period of 1, January to 31, December 2010. Patients should be diagnosed as having schizophrenia, schizoaffective disorder, schizophreniform disorder, brief psychotic disorder, delusional disorder or psychotic disorder not otherwise specified. Results In 2010, 260 patients in SMH were prescribed with antipsychotics and 47.3% (n=123) of them were discharged under antipsychotic polypharmacy treatment. The most commonly prescribed antipsychotics for combination therapy was quetiapine (n=64). The most prevalent combination of drugs was risperidone plus quetiapine (n=20). Logistic regression analysis showed that the use of high-dose antipsychotics, first-generation antipsychotics, and long hospital duration were significantly associated with antipsychotic polypharmacy. Conclusion Although the controlled evidence for efficacy and safety as a strategy remains inconclusive, antipsychotic polypharmacy is a common pharmacological strategy as it is illustrated in our study. Considering high antipsychotic doses related with antipsychotic polypharmacy, careful monitoring of side effect and efficacy is needed.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Hyung(김찬형)
Roh, Dae Young(노대영)
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Cho, Hyun Sang(조현상) ORCID logo https://orcid.org/0000-0003-1019-9941
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