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Transcription factor Snail is a novel regulator of adipocyte differentiation via inhibiting the expression of peroxisome proliferator-activated receptor γ

Authors
 Yong-ho Lee  ;  Soo Hyun Kim  ;  Yoo Jeong Lee  ;  Eun Seok Kang  ;  Byung-Wan Lee  ;  Bong Soo Cha  ;  Jae Woo Kim  ;  Dae Hyun Song  ;  Hyun Chul Lee 
Citation
 Cellular and Molecular Life Sciences, Vol.70(20) : 3959-3971, 2013 
Journal Title
 Cellular and Molecular Life Sciences 
ISSN
 1420-682X 
Issue Date
2013
Abstract
Epidermolysis bullosa acquisita (EBA) is a chronic autoimmune subepidermal bullous disease with clinical features similar to the genetic form of dystrophic epidermolysis bullosa. EBA is characterized by the presence of autoantibodies against type VII collagen which is a major component of the anchoring fibrils at the dermal-epidermal junction. EBA can be divided into two main clinical types; mechanobullous and inflammatory EBA. Mechanobullous EBA, referred to as classic EBA, presents with skin fragility, blisters and dystrophic changes on trauma-prone areas. Inflammatory EBA resembles other autoimmune subepidermal bullous diseases. Compelling evidence from mouse models supports a pathogenic role of autoantibodies against type VII collagen in EBA. Treatment of EBA is often unsatisfactory. The most widely used systemic treatment is corticosteroids. Colchicine and dapsone have been reported to be good treatment modalities when combined with corticosteroids. Some intractable cases of EBA have successfully been treated with intravenous immunoglobulin or rituximab.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/jdv.12096/abstract
DOI
10.1007/s00018-013-1363-8
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강은석(Kang, Eun Seok) ORCID logo https://orcid.org/0000-0002-0364-4675
김수현(Kim, Soo Hyun)
김재우(Kim, Jae Woo) ORCID logo https://orcid.org/0000-0001-5456-9495
이병완(Lee, Byung Wan)
이용호(Lee, Yong Ho) ORCID logo https://orcid.org/0000-0002-6219-4942
이유정(Lee, Yoo Jeong)
이현철(Lee, Hyun Chul)
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89110
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