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Immature platelet fraction in diabetes mellitus and metabolic syndrome

Authors
 Eun Young Lee  ;  Sue Jung Kim  ;  Yea Jin Song  ;  Seung Jun Choi  ;  Jaewoo Song 
Citation
 THROMBOSIS RESEARCH, Vol.132(6) : 692-695, 2013 
Journal Title
THROMBOSIS RESEARCH
ISSN
 0049-3848 
Issue Date
2013
MeSH
Blood Platelets/metabolism* ; Blood Platelets/pathology ; Case-Control Studies ; Diabetes Mellitus/blood* ; Female ; Humans ; Male ; Metabolic Syndrome/blood* ; Middle Aged
Keywords
Diabetes mellitus ; Immature platelet fraction ; Mean platelet volume ; Metabolic syndrome
Abstract
INTRODUCTION:
Dysregulated platelet-endothelial interaction plays a pivotal role in atherothrombotic events in patients with diabetes mellitus (DM). Immature platelet fraction (IPF) is a hematologic parameter of automated hematologic analyzer and is related to platelet size and cytoplasmic RNA contents. It reflects thrombopoiesis and also is often used as the marker of platelet activity.
MATERIAL AND METHODS:
We compared peripheral blood IPF, IPF count (IPC), and mean platelet volume (MPV) of DM and metabolic syndrome (MetS) patients with those of healthy controls. The IPF, IPC, MPV, and other blood cell indices were measured.
RESULTS:
The DM group had significantly higher IPF (2.20 vs. 1.70%, P=.020), IPC (4.80 vs. 4.60×10(9)/L, P=.043), and MPV (10.35 vs. 10.00fL, P=.012) than the control group. Those markers were also increased in MetS patients, but the differences were not statistically significant. Interestingly, when DM patients were stratified according to glycemic control status (≤6.5% HbA1c vs. 6.6-7.9% HbA1c vs. ≥8% HbA1c), both IPF and IPC were significantly increased in poor glycemic control group (P=.014 and .003). Including various diabetic complications in the analysis, IPF was higher in DM patients complicated by cardiovascular disease than the DM group without cardiovascular disease.
CONCLUSION:
IPF is elevated in patients with diabetes and associated with poor glycemic control and cardiovascular complication.
Full Text
http://www.sciencedirect.com/science/article/pii/S0049384813004490
DOI
10.1016/j.thromres.2013.09.035
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Sue Jeong(김수정)
Song, Yea Jin(송예진)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Lee, Eun Young(이은영)
Choi, Seung Jun(최승준) ORCID logo https://orcid.org/0000-0003-0736-1055
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89100
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