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Glioma Grading Capability: Comparisons among Parameters from Dynamic Contrast-Enhanced MRI and ADC Value on DWI

 Hyun Seok Choi  ;  Ah Hyun Kim  ;  Sung Soo Ahn  ;  Na-young Shin  ;  Jinna Kim  ;  Seung-Koo Lee 
 KOREAN JOURNAL OF RADIOLOGY, Vol.14(3) : 487-492, 2013 
Journal Title
Issue Date
Adult ; Aged ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology* ; Contrast Media* ; Diffusion Magnetic Resonance Imaging/methods* ; Extracellular Space/metabolism ; Female ; Glioma/metabolism ; Glioma/pathology* ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neoplasm Grading ; Permeability ; ROC Curve ; Sensitivity and Specificity
Apparent diffusion coefficient ; Dynamic contrast-enhanced MRI ; Glioma
OBJECTIVE: Permeability parameters from dynamic contrast-enhanced MRI (DCE-MRI) and apparent diffusion coefficient (ADC) value on diffusion-weighted imaging (DWI) can be quantitative physiologic metrics for gliomas. The transfer constant (K(trans)) has shown efficacy in grading gliomas. Volume fraction of extravascular extracellular space (ve) has been underutilized to grade gliomas. The purpose of this study was to evaluate ve in its ability to grade gliomas and to assess the correlation with other permeability parameters and ADC values. MATERIALS AND METHODS: A total of 33 patients diagnosed with pathologically-confirmed gliomas were examined by 3 T MRI including DCE-MRI and ADC map. A region of interest analyses for permeability parameters from DCE-MRI and ADC were performed on the enhancing solid portion of the tumors. Permeability parameters form DCE-MRI and ADC between low- and high-grade gliomas; the diagnostic performances of presumptive metrics and correlation among those metrics were statistically analyzed. RESULTS: High-grade gliomas showed higher K(trans) (0.050 vs. 0.010 in median value, p = 0.002) and higher ve (0.170 vs. 0.015 in median value, p = 0.001) than low-grade gliomas. Receiver operating characteristic curve analysis showed significance in both K(trans) and ve for glioma grading. However, there was no significant difference in diagnostic performance between K(trans) and ve. ADC value did not correlate with any of the permeability parameters from DCE-MRI. CONCLUSION: Extravascular extracellular space (ve) appears to be comparable with transfer constant (K(trans)) in differentiating high-grade gliomas from low-grade gliomas. ADC value does not show correlation with any permeability parameters from DCE-MRI.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ah Hyun(김아현)
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Shin, Na Young(신나영)
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-0503-5558
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Choi, Hyun Seok(최현석) ORCID logo https://orcid.org/0000-0003-4999-8513
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