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Optimization of the radiosynthesis of [F-18]MEFWAY for imaging brain serotonin 1A receptors by using the GE TracerLab FXFN-Pro module

Authors
 Jae Yong Choi  ;  Chul Hoon Kim  ;  Young Hoon Ryu  ;  Young Beom Seo  ;  Phong Truong  ;  Eun Jung Kim  ;  Tae Hyun Choi  ;  JeeHae Kang  ;  Minkyung Lee  ;  Dong Goo Kim  ;  Jong Doo Lee  ;  Tae Joo Jeon 
Citation
 JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol.56(12) : 589-594, 2013 
Journal Title
 JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 
ISSN
 0362-4803 
Issue Date
2013
MeSH
Fluorine Radioisotopes/chemistry* ; Isotope Labeling/methods* ; Piperazines/chemical synthesis* ; Pyridines/chemical synthesis* ; Radiopharmaceuticals/chemical synthesis*
Keywords
Mefway ; PET ; automated radiosynthesis ; serotonin 1A receptor
Abstract
The aim of this study was to develop a highly reliable radiofluorination method for the preparation of N-{2-[4-(2-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4-18F-fluoromethylcyclohexane)carboxamide ([18F]Mefway) by using a fully automated system. The optimal condition is composed of two parts. The extraction system of the trapped F-18 in the anion exchange resin (i.e., quaternary methylamine cartridge) is a complex of Kryptofix 2.2.2. (K222, 4 mg/0.9 mL methanol) and K2CO3 (1 mg/0.1 mL H2O). After removing the solvents, the trans-tosylated Mefway precursor (1 mg/0.5 mL acetonitrile) was reacted with dried K222-K[18F] at 100°C for 5 min. After purification and formulation, [18F]Mefway was obtained with 38 ± 2.4% (decay corrected, n = 34) radiochemical yield, a total synthesis time of 52 ± 3.4 min, specific activity was 120.6 ± 8.7 GBq/µmol at the end of synthesis and a radiochemical purity of 99%. According to the quality control tests, formulated [18F]Mefway is suitable to apply parenteral clinical application.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3067/abstract
DOI
10.1002/jlcr.3067
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Goo(김동구)
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Jong Doo(이종두)
Jeon, Tae Joo(전태주) ORCID logo https://orcid.org/0000-0002-7574-6734
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89037
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