Cited 8 times in
Optimization of the radiosynthesis of [F-18]MEFWAY for imaging brain serotonin 1A receptors by using the GE TracerLab FXFN-Pro module
DC Field | Value | Language |
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dc.contributor.author | 김동구 | - |
dc.contributor.author | 김철훈 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 이종두 | - |
dc.contributor.author | 전태주 | - |
dc.date.accessioned | 2014-12-18T09:53:58Z | - |
dc.date.available | 2014-12-18T09:53:58Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0362-4803 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89037 | - |
dc.description.abstract | The aim of this study was to develop a highly reliable radiofluorination method for the preparation of N-{2-[4-(2-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4-18F-fluoromethylcyclohexane)carboxamide ([18F]Mefway) by using a fully automated system. The optimal condition is composed of two parts. The extraction system of the trapped F-18 in the anion exchange resin (i.e., quaternary methylamine cartridge) is a complex of Kryptofix 2.2.2. (K222, 4 mg/0.9 mL methanol) and K2CO3 (1 mg/0.1 mL H2O). After removing the solvents, the trans-tosylated Mefway precursor (1 mg/0.5 mL acetonitrile) was reacted with dried K222-K[18F] at 100°C for 5 min. After purification and formulation, [18F]Mefway was obtained with 38 ± 2.4% (decay corrected, n = 34) radiochemical yield, a total synthesis time of 52 ± 3.4 min, specific activity was 120.6 ± 8.7 GBq/µmol at the end of synthesis and a radiochemical purity of 99%. According to the quality control tests, formulated [18F]Mefway is suitable to apply parenteral clinical application. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Fluorine Radioisotopes/chemistry* | - |
dc.subject.MESH | Isotope Labeling/methods* | - |
dc.subject.MESH | Piperazines/chemical synthesis* | - |
dc.subject.MESH | Pyridines/chemical synthesis* | - |
dc.subject.MESH | Radiopharmaceuticals/chemical synthesis* | - |
dc.title | Optimization of the radiosynthesis of [F-18]MEFWAY for imaging brain serotonin 1A receptors by using the GE TracerLab FXFN-Pro module | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Jae Yong Choi | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.contributor.googleauthor | Young Beom Seo | - |
dc.contributor.googleauthor | Phong Truong | - |
dc.contributor.googleauthor | Eun Jung Kim | - |
dc.contributor.googleauthor | Tae Hyun Choi | - |
dc.contributor.googleauthor | JeeHae Kang | - |
dc.contributor.googleauthor | Minkyung Lee | - |
dc.contributor.googleauthor | Dong Goo Kim | - |
dc.contributor.googleauthor | Jong Doo Lee | - |
dc.contributor.googleauthor | Tae Joo Jeon | - |
dc.identifier.doi | 10.1002/jlcr.3067 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03557 | - |
dc.contributor.localId | A00396 | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A03138 | - |
dc.relation.journalcode | J01554 | - |
dc.identifier.eissn | 1099-1344 | - |
dc.identifier.pmid | 24285234 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3067/abstract | - |
dc.subject.keyword | Mefway | - |
dc.subject.keyword | PET | - |
dc.subject.keyword | automated radiosynthesis | - |
dc.subject.keyword | serotonin 1A receptor | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.alternativeName | Lee, Jong Doo | - |
dc.contributor.alternativeName | Jeon, Tae Joo | - |
dc.contributor.affiliatedAuthor | Jeon, Tae Joo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Ryu, Young Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Jong Doo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 56 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 589 | - |
dc.citation.endPage | 594 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol.56(12) : 589-594, 2013 | - |
dc.identifier.rimsid | 33757 | - |
dc.type.rims | ART | - |
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