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마이크로와이어 기반 nitric oxide 가스 측정 센서의 개발 및 그 유용성에 대한 기초연구

Other Titles
 Fabrication of a nitric oxide gas sensor using microwires and basic research for its application 
 이상우  ;  민선옥  ;  이경훈  ;  권대성  ;  임진홍  ;  남기창  ;  김종백  ;  김경식 
 Korean Journal of Clinical Oncology (대한임상종양학회지), Vol.9(2) : 109-114, 2013 
Journal Title
 Korean Journal of Clinical Oncology (대한임상종양학회지) 
Issue Date
Liver regeneration ; Nitric oxide ; Hepatectomy ; Liver ischemia
Purpose: Although nitric oxide (NO) is considered one of the initial signals that promote postsurgery liver regeneration, NO’s exact role in the liver regeneration mechanism is still not clear. Therefore, developing a practical gas sensor and testing it in a clinical setting through basic research will lay the groundwork for advanced clinical research on the action mechanism of NO. Methods: A thin nano wire NO sensor was made by wrapping a pair of parlyene-coated gold wires around a needle. The NO blood concentration determined by measuring the potential difference across the oscilloscope using electrical conductivity. In order to measure changes in NO level before and after the surgery, the NO sensor was inserted in the hepatic portal vein and a 75 percent partial hepatectomy was performed. The NO blood concentration was measured regularly with both the NO kit and the sensor. Results: One significant challenge was separation of the wire upon insertion into the hepatic portal vein. Despite separation, the constant measurements of the wire-type sensor were similar to those measured by the NO measurement kit. Conclusion: The development of a needle-type sensor allowed for easier insertion. In the future, using difference in electric potential, as used in the NO sensor, may be a more effective method of measuring blood ion concentration.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Nam, Ki Chang(남기창)
Min, Seon Ok(민선옥)
Lee, Sang Woo(이상우)
Lim, Jin Hong(임진홍)
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