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Antimicrobial Resistance and Molecular Epidemiologic Characteristics of Neisseria gonorrhoeae Isolated from Korea in 2013

Authors
 Hyo Jin Kim  ;  Younghee Seo  ;  Wan Hee Kim  ;  Yangsoon Lee  ;  Hyukmin Lee  ;  Kyungwon Lee  ;  Yunsop Chong 
Citation
 Annals of Clinical Microbiology, Vol.16(4) : 182-187, 2013 
Journal Title
 Annals of Clinical Microbiology 
ISSN
 2288-0585 
Issue Date
2013
Keywords
Microbial sensitivity tests ; Neisseria gonorrhoeae ; Neisseria gonorrhoeae multiantigen sequence typing
Abstract
Background : Antimicrobial resistance of Neisseria gonorrhoeae has become a serious problem worldwide, and ceftriaxone non-susceptible isolates have been recently reported from Japan and Europe. In this study, we evaluated the antimicrobial susceptibilities and molecular epidemiological characteristics of isolates from Korea in 2013. Methods : Sixty strains of N. gonorrhoeae were collected from Korean patients and prostitutes. Antimicrobial susceptibility was tested by the agar dilution and disk diffusion methods. N. gonorrhoeae multi-antigen sequence typing (NG-MAST) was performed in order to determine the molecular epidemiologic relatedness. Results : All of isolates were non-susceptible to penicillin G and tetracycline, and the rate of ciprofloxacinresistant isolates was 95% in 2013. The MICs of ceftriaxone were within the susceptible range for all isolates, but one isolate non-susceptible to cefixime (MIC=0.5 µg/mL) was encountered. The isolates with decreased susceptibility (MIC≤0.12 µg/mL) to cefixime or ceftriaxone accounted for 10% and 14% of the isolates tested, respectively. In NG-MAST analysis, 40 different STs were encountered among the 59 isolates. Isolates that belonged to tbpB110 showed higher cefixime and ceftriaxone MICs (0.12-0.5 µg/mL) as well as cefixime resistance. Conclusion : Most of the N. gonorrhoeae isolates showed susceptibility to spectinomycin and cephalosporins. Due to the emergence of isolates that are non-susceptible to cefixime and the prevalence of isolates with the tbpB110 allele belonging to ST1407, which cause cefixime and ceftriaxone treatment failure in successful global clones of N. gonorrhoeae, a continuous nationwide antimicrobial surveillance program is required to monitor the emergence of cephalosporin resistance in N. gonorrhoeae
Files in This Item:
T201305198.pdf Download
DOI
10.5145/ACM.2013.16.4.182
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Wan Hee(김완희)
Kim, Hyo Jin(김효진)
Seo, Young Hee(서영희)
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Lee, Yang Soon(이양순)
Chong, Yun Sop(정윤섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88823
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