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Antimicrobial Resistance and Molecular Epidemiologic Characteristics of Neisseria gonorrhoeae Isolated from Korea in 2013
DC Field | Value | Language |
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dc.contributor.author | 김완희 | - |
dc.contributor.author | 김효진 | - |
dc.contributor.author | 서영희 | - |
dc.contributor.author | 이경원 | - |
dc.contributor.author | 이양순 | - |
dc.contributor.author | 정윤섭 | - |
dc.date.accessioned | 2014-12-18T09:47:05Z | - |
dc.date.available | 2014-12-18T09:47:05Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2288-0585 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88823 | - |
dc.description.abstract | Background : Antimicrobial resistance of Neisseria gonorrhoeae has become a serious problem worldwide, and ceftriaxone non-susceptible isolates have been recently reported from Japan and Europe. In this study, we evaluated the antimicrobial susceptibilities and molecular epidemiological characteristics of isolates from Korea in 2013. Methods : Sixty strains of N. gonorrhoeae were collected from Korean patients and prostitutes. Antimicrobial susceptibility was tested by the agar dilution and disk diffusion methods. N. gonorrhoeae multi-antigen sequence typing (NG-MAST) was performed in order to determine the molecular epidemiologic relatedness. Results : All of isolates were non-susceptible to penicillin G and tetracycline, and the rate of ciprofloxacinresistant isolates was 95% in 2013. The MICs of ceftriaxone were within the susceptible range for all isolates, but one isolate non-susceptible to cefixime (MIC=0.5 µg/mL) was encountered. The isolates with decreased susceptibility (MIC≤0.12 µg/mL) to cefixime or ceftriaxone accounted for 10% and 14% of the isolates tested, respectively. In NG-MAST analysis, 40 different STs were encountered among the 59 isolates. Isolates that belonged to tbpB110 showed higher cefixime and ceftriaxone MICs (0.12-0.5 µg/mL) as well as cefixime resistance. Conclusion : Most of the N. gonorrhoeae isolates showed susceptibility to spectinomycin and cephalosporins. Due to the emergence of isolates that are non-susceptible to cefixime and the prevalence of isolates with the tbpB110 allele belonging to ST1407, which cause cefixime and ceftriaxone treatment failure in successful global clones of N. gonorrhoeae, a continuous nationwide antimicrobial surveillance program is required to monitor the emergence of cephalosporin resistance in N. gonorrhoeae | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | Annals of Clinical Microbiology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Antimicrobial Resistance and Molecular Epidemiologic Characteristics of Neisseria gonorrhoeae Isolated from Korea in 2013 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Hyo Jin Kim | - |
dc.contributor.googleauthor | Younghee Seo | - |
dc.contributor.googleauthor | Wan Hee Kim | - |
dc.contributor.googleauthor | Yangsoon Lee | - |
dc.contributor.googleauthor | Hyukmin Lee | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.contributor.googleauthor | Yunsop Chong | - |
dc.identifier.doi | 10.5145/ACM.2013.16.4.182 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00739 | - |
dc.contributor.localId | A01206 | - |
dc.contributor.localId | A01895 | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A02947 | - |
dc.contributor.localId | A03679 | - |
dc.relation.journalcode | J00156 | - |
dc.identifier.pmid | Microbial sensitivity tests ; Neisseria gonorrhoeae ; Neisseria gonorrhoeae multiantigen sequence typing | - |
dc.subject.keyword | Microbial sensitivity tests | - |
dc.subject.keyword | Neisseria gonorrhoeae | - |
dc.subject.keyword | Neisseria gonorrhoeae multiantigen sequence typing | - |
dc.contributor.alternativeName | Kim, Wan Hee | - |
dc.contributor.alternativeName | Kim, Hyo Jin | - |
dc.contributor.alternativeName | Seo, Young Hee | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.alternativeName | Lee, Yang Soon | - |
dc.contributor.alternativeName | Chong, Yun Sop | - |
dc.contributor.affiliatedAuthor | Kim, Wan Hee | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Jin | - |
dc.contributor.affiliatedAuthor | Seo, Young Hee | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Lee, Yang Soon | - |
dc.contributor.affiliatedAuthor | Chong, Yun Sop | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 16 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 182 | - |
dc.citation.endPage | 187 | - |
dc.identifier.bibliographicCitation | Annals of Clinical Microbiology, Vol.16(4) : 182-187, 2013 | - |
dc.identifier.rimsid | 33643 | - |
dc.type.rims | ART | - |
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