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Plasma klotho levels were inversely associated with subclinical carotid atherosclerosis in HIV-infected patients receiving combined antiretroviral therapy

Authors
 Su Jin Jeong  ;  Je Eun Song  ;  Sun Bean Kim  ;  Hye-won Kim  ;  Nam Su Ku  ;  Sang Hoon Han  ;  Jun Yong Choi  ;  Young Goo Song  ;  Bong Soo Cha  ;  June Myung Kim 
Citation
 AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol.29(12) : 1575-1581, 2013 
Journal Title
 AIDS RESEARCH AND HUMAN RETROVIRUSES 
ISSN
 0889-2229 
Issue Date
2013
MeSH
Adult ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/therapeutic use* ; Carotid Artery Diseases/blood* ; Carotid Artery Diseases/complications ; Drug Therapy, Combination ; Female ; Glucuronidase/blood* ; HIV Infections/blood* ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Limit of Detection ; Male ; Prospective Studies
Keywords
Adult ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/therapeutic use* ; Carotid Artery Diseases/blood* ; Carotid Artery Diseases/complications ; Drug Therapy, Combination ; Female ; Glucuronidase/blood* ; HIV Infections/blood* ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Limit of Detection ; Male ; Prospective Studies
Abstract
Combined antiretroviral therapy (cART) has significantly improved the survival rate in HIV-infected individuals, but it contributes to the development of various metabolic complications. Klotho is a novel antiaging gene that encodes a protein with pleiotropic functions, including an emerging role in cardiovascular disease (CVD). The protective effect of higher plasma klotho levels against CVD was recently observed in non-HIV-infected adults. We aimed to assess whether plasma-secreted α-klotho is associated with subclinical carotid atherosclerosis in HIV-infected patients receiving cART. We prospectively examined the association of circulating plasma α-klotho in 120 HIV-infected patients who had received cART for ≥6 months with intima-media thickness (IMT) in the carotid artery and other metabolic variables. The subclinical carotid atherosclerosis was defined as an increased mean IMT level of ≥75th percentile for the matched age, sex, and race and/or the presence of carotid plaque. Thirty-four (28.3%) of 120 had subclinical carotid atherosclerosis. The higher plasma levels of α-klotho had protective effect against subclinical carotid atherosclerosis (OR 0.006, p=0.034) in multivariate regression analysis. Plasma α-klotho levels had a significantly negative correlation with fasting glucose levels (r=-0.216, p=0.018) and mean IMT (r=-0.258, p=0.004) in multiple stepwise regression analyses. The optimal cutoff values of plasma α-klotho levels for the greatest sensitivity and specificity were calculated as 2.83 log10 [pg/ml] (sensitivity, 48.7%; specificity, 90.5%). These results show that plasma klotho levels were inversely associated with subclinical carotid atherosclerosis in HIV-infected patients receiving cART
Full Text
http://online.liebertpub.com/doi/abs/10.1089/aid.2013.0048
DOI
10.1089/aid.2013.0048
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Sun Bean(김선빈)
Kim, June Myung(김준명)
Kim, Hye Won(김혜원)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Song, Je Eun(송제은)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88787
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