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Plasma klotho levels were inversely associated with subclinical carotid atherosclerosis in HIV-infected patients receiving combined antiretroviral therapy

DC FieldValueLanguage
dc.contributor.author김준명-
dc.contributor.author김혜원-
dc.contributor.author송영구-
dc.contributor.author송제은-
dc.contributor.author정수진-
dc.contributor.author차봉수-
dc.contributor.author최준용-
dc.contributor.author한상훈-
dc.contributor.author구남수-
dc.contributor.author김선빈-
dc.date.accessioned2014-12-18T09:45:57Z-
dc.date.available2014-12-18T09:45:57Z-
dc.date.issued2013-
dc.identifier.issn0889-2229-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88787-
dc.description.abstractCombined antiretroviral therapy (cART) has significantly improved the survival rate in HIV-infected individuals, but it contributes to the development of various metabolic complications. Klotho is a novel antiaging gene that encodes a protein with pleiotropic functions, including an emerging role in cardiovascular disease (CVD). The protective effect of higher plasma klotho levels against CVD was recently observed in non-HIV-infected adults. We aimed to assess whether plasma-secreted α-klotho is associated with subclinical carotid atherosclerosis in HIV-infected patients receiving cART. We prospectively examined the association of circulating plasma α-klotho in 120 HIV-infected patients who had received cART for ≥6 months with intima-media thickness (IMT) in the carotid artery and other metabolic variables. The subclinical carotid atherosclerosis was defined as an increased mean IMT level of ≥75th percentile for the matched age, sex, and race and/or the presence of carotid plaque. Thirty-four (28.3%) of 120 had subclinical carotid atherosclerosis. The higher plasma levels of α-klotho had protective effect against subclinical carotid atherosclerosis (OR 0.006, p=0.034) in multivariate regression analysis. Plasma α-klotho levels had a significantly negative correlation with fasting glucose levels (r=-0.216, p=0.018) and mean IMT (r=-0.258, p=0.004) in multiple stepwise regression analyses. The optimal cutoff values of plasma α-klotho levels for the greatest sensitivity and specificity were calculated as 2.83 log10 [pg/ml] (sensitivity, 48.7%; specificity, 90.5%). These results show that plasma klotho levels were inversely associated with subclinical carotid atherosclerosis in HIV-infected patients receiving cART-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfAIDS Research and Human Retroviruses-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAnti-HIV Agents/administration & dosage-
dc.subject.MESHAnti-HIV Agents/therapeutic use*-
dc.subject.MESHCarotid Artery Diseases/blood*-
dc.subject.MESHCarotid Artery Diseases/complications-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHGlucuronidase/blood*-
dc.subject.MESHHIV Infections/blood*-
dc.subject.MESHHIV Infections/complications-
dc.subject.MESHHIV Infections/drug therapy-
dc.subject.MESHHumans-
dc.subject.MESHLimit of Detection-
dc.subject.MESHMale-
dc.subject.MESHProspective Studies-
dc.titlePlasma klotho levels were inversely associated with subclinical carotid atherosclerosis in HIV-infected patients receiving combined antiretroviral therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorJe Eun Song-
dc.contributor.googleauthorSun Bean Kim-
dc.contributor.googleauthorHye-won Kim-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorBong Soo Cha-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.1089/aid.2013.0048-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00953-
dc.contributor.localIdA01176-
dc.contributor.localIdA02037-
dc.contributor.localIdA02059-
dc.contributor.localIdA03638-
dc.contributor.localIdA03996-
dc.contributor.localIdA04191-
dc.contributor.localIdA04286-
dc.contributor.localIdA00189-
dc.contributor.localIdA00547-
dc.relation.journalcodeJ00055-
dc.identifier.pmid23941507-
dc.identifier.urlhttp://online.liebertpub.com/doi/abs/10.1089/aid.2013.0048-
dc.subject.keywordAdult-
dc.subject.keywordAnti-HIV Agents/administration & dosage-
dc.subject.keywordAnti-HIV Agents/therapeutic use*-
dc.subject.keywordCarotid Artery Diseases/blood*-
dc.subject.keywordCarotid Artery Diseases/complications-
dc.subject.keywordDrug Therapy, Combination-
dc.subject.keywordFemale-
dc.subject.keywordGlucuronidase/blood*-
dc.subject.keywordHIV Infections/blood*-
dc.subject.keywordHIV Infections/complications-
dc.subject.keywordHIV Infections/drug therapy-
dc.subject.keywordHumans-
dc.subject.keywordLimit of Detection-
dc.subject.keywordMale-
dc.subject.keywordProspective Studies-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Hye Won-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameSong, Je Eun-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.alternativeNameKim, Sun Bean-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorKim, Hye Won-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorSong, Je Eun-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.contributor.affiliatedAuthorKu, Nam Su-
dc.contributor.affiliatedAuthorKim, Sun Bean-
dc.rights.accessRightsnot free-
dc.citation.volume29-
dc.citation.number12-
dc.citation.startPage1575-
dc.citation.endPage1581-
dc.identifier.bibliographicCitationAIDS Research and Human Retroviruses, Vol.29(12) : 1575-1581, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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