Cited 13 times in
Plasma klotho levels were inversely associated with subclinical carotid atherosclerosis in HIV-infected patients receiving combined antiretroviral therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김준명 | - |
dc.contributor.author | 김혜원 | - |
dc.contributor.author | 송영구 | - |
dc.contributor.author | 송제은 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 최준용 | - |
dc.contributor.author | 한상훈 | - |
dc.contributor.author | 구남수 | - |
dc.contributor.author | 김선빈 | - |
dc.date.accessioned | 2014-12-18T09:45:57Z | - |
dc.date.available | 2014-12-18T09:45:57Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0889-2229 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88787 | - |
dc.description.abstract | Combined antiretroviral therapy (cART) has significantly improved the survival rate in HIV-infected individuals, but it contributes to the development of various metabolic complications. Klotho is a novel antiaging gene that encodes a protein with pleiotropic functions, including an emerging role in cardiovascular disease (CVD). The protective effect of higher plasma klotho levels against CVD was recently observed in non-HIV-infected adults. We aimed to assess whether plasma-secreted α-klotho is associated with subclinical carotid atherosclerosis in HIV-infected patients receiving cART. We prospectively examined the association of circulating plasma α-klotho in 120 HIV-infected patients who had received cART for ≥6 months with intima-media thickness (IMT) in the carotid artery and other metabolic variables. The subclinical carotid atherosclerosis was defined as an increased mean IMT level of ≥75th percentile for the matched age, sex, and race and/or the presence of carotid plaque. Thirty-four (28.3%) of 120 had subclinical carotid atherosclerosis. The higher plasma levels of α-klotho had protective effect against subclinical carotid atherosclerosis (OR 0.006, p=0.034) in multivariate regression analysis. Plasma α-klotho levels had a significantly negative correlation with fasting glucose levels (r=-0.216, p=0.018) and mean IMT (r=-0.258, p=0.004) in multiple stepwise regression analyses. The optimal cutoff values of plasma α-klotho levels for the greatest sensitivity and specificity were calculated as 2.83 log10 [pg/ml] (sensitivity, 48.7%; specificity, 90.5%). These results show that plasma klotho levels were inversely associated with subclinical carotid atherosclerosis in HIV-infected patients receiving cART | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | AIDS RESEARCH AND HUMAN RETROVIRUSES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anti-HIV Agents/administration & dosage | - |
dc.subject.MESH | Anti-HIV Agents/therapeutic use* | - |
dc.subject.MESH | Carotid Artery Diseases/blood* | - |
dc.subject.MESH | Carotid Artery Diseases/complications | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucuronidase/blood* | - |
dc.subject.MESH | HIV Infections/blood* | - |
dc.subject.MESH | HIV Infections/complications | - |
dc.subject.MESH | HIV Infections/drug therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Limit of Detection | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Prospective Studies | - |
dc.title | Plasma klotho levels were inversely associated with subclinical carotid atherosclerosis in HIV-infected patients receiving combined antiretroviral therapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Je Eun Song | - |
dc.contributor.googleauthor | Sun Bean Kim | - |
dc.contributor.googleauthor | Hye-won Kim | - |
dc.contributor.googleauthor | Nam Su Ku | - |
dc.contributor.googleauthor | Sang Hoon Han | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Young Goo Song | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | June Myung Kim | - |
dc.identifier.doi | 10.1089/aid.2013.0048 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A01176 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A02059 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A04286 | - |
dc.contributor.localId | A00189 | - |
dc.contributor.localId | A00547 | - |
dc.relation.journalcode | J00055 | - |
dc.identifier.eissn | 1931-8405 | - |
dc.identifier.pmid | 23941507 | - |
dc.identifier.url | http://online.liebertpub.com/doi/abs/10.1089/aid.2013.0048 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Anti-HIV Agents/administration & dosage | - |
dc.subject.keyword | Anti-HIV Agents/therapeutic use* | - |
dc.subject.keyword | Carotid Artery Diseases/blood* | - |
dc.subject.keyword | Carotid Artery Diseases/complications | - |
dc.subject.keyword | Drug Therapy, Combination | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Glucuronidase/blood* | - |
dc.subject.keyword | HIV Infections/blood* | - |
dc.subject.keyword | HIV Infections/complications | - |
dc.subject.keyword | HIV Infections/drug therapy | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Limit of Detection | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Prospective Studies | - |
dc.contributor.alternativeName | Kim, June Myung | - |
dc.contributor.alternativeName | Kim, Hye Won | - |
dc.contributor.alternativeName | Song, Young Goo | - |
dc.contributor.alternativeName | Song, Je Eun | - |
dc.contributor.alternativeName | Jeong, Su Jin | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.alternativeName | Han, Sang Hoon | - |
dc.contributor.alternativeName | Ku, Nam Su | - |
dc.contributor.alternativeName | Kim, Sun Bean | - |
dc.contributor.affiliatedAuthor | Kim, June Myung | - |
dc.contributor.affiliatedAuthor | Kim, Hye Won | - |
dc.contributor.affiliatedAuthor | Song, Young Goo | - |
dc.contributor.affiliatedAuthor | Song, Je Eun | - |
dc.contributor.affiliatedAuthor | Jeong, Su Jin | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | Han, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Ku, Nam Su | - |
dc.contributor.affiliatedAuthor | Kim, Sun Bean | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1575 | - |
dc.citation.endPage | 1581 | - |
dc.identifier.bibliographicCitation | AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol.29(12) : 1575-1581, 2013 | - |
dc.identifier.rimsid | 33621 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.