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Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity

Authors
 Jiyoung Y. Cha  ;  Hyo Jung Kim  ;  Jung Hwan Yu  ;  Jing Xu  ;  Daham Kim  ;  Bindu D. Paul  ;  Hyeonjin Choi  ;  Seyun Kim  ;  Yoo Jeong Lee  ;  Gary P. Ho  ;  Feng Rao  ;  Solomon H. Snyder  ;  Jae-woo Kim 
Citation
 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.110(51) : 20575-20580, 2013 
Journal Title
 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 
ISSN
 0027-8424 
Issue Date
2013
MeSH
3T3-L1 Cells ; Adipogenesis/drug effects* ; Adipogenesis/genetics ; Animals ; Cell Differentiation/drug effects* ; Dexamethasone/adverse effects* ; Dexamethasone/pharmacology ; Diet/adverse effects ; Glucocorticoids/adverse effects* ; Glucocorticoids/pharmacology ; Mice ; Mice, Knockout ; Obesity/chemically induced* ; Obesity/genetics ; Obesity/metabolism ; Obesity/pathology ; ras Proteins/genetics ; ras Proteins/metabolism*
Keywords
Cushing disease ; cyclic AMP ; insulin ; nitric oxide
Abstract
Adipogenesis, the conversion of precursor cells into adipocytes, is associated with obesity and is mediated by glucocorticoids acting via hitherto poorly characterized mechanisms. Dexras1 is a small G protein of the Ras family discovered on the basis of its marked induction by the synthetic glucocorticoid dexamethasone. We show that Dexras1 mediates adipogenesis and diet-induced obesity. Adipogenic differentiation of 3T3-L1 cells is abolished with Dexras1 depletion, whereas overexpression of Dexras1 elicits adipogenesis. Adipogenesis is markedly reduced in mouse embryonic fibroblasts from Dexras1-deleted mice, whereas adiposity and diet-induced weight gain are diminished in the mutant mice.
Full Text
http://www.pnas.org/content/110/51/20575.long
DOI
10.1073/pnas.1320454110
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Daham(김다함) ORCID logo https://orcid.org/0000-0003-1871-686X
Kim, Jae Woo(김재우) ORCID logo https://orcid.org/0000-0001-5456-9495
Kim, Hyo Jung(김효정) ORCID logo https://orcid.org/0000-0002-3514-1247
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88761
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