Cited 30 times in
Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김재우 | - |
dc.contributor.author | 김효정 | - |
dc.contributor.author | 김다함 | - |
dc.date.accessioned | 2014-12-18T09:45:10Z | - |
dc.date.available | 2014-12-18T09:45:10Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88761 | - |
dc.description.abstract | Adipogenesis, the conversion of precursor cells into adipocytes, is associated with obesity and is mediated by glucocorticoids acting via hitherto poorly characterized mechanisms. Dexras1 is a small G protein of the Ras family discovered on the basis of its marked induction by the synthetic glucocorticoid dexamethasone. We show that Dexras1 mediates adipogenesis and diet-induced obesity. Adipogenic differentiation of 3T3-L1 cells is abolished with Dexras1 depletion, whereas overexpression of Dexras1 elicits adipogenesis. Adipogenesis is markedly reduced in mouse embryonic fibroblasts from Dexras1-deleted mice, whereas adiposity and diet-induced weight gain are diminished in the mutant mice. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 3T3-L1 Cells | - |
dc.subject.MESH | Adipogenesis/drug effects* | - |
dc.subject.MESH | Adipogenesis/genetics | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Differentiation/drug effects* | - |
dc.subject.MESH | Dexamethasone/adverse effects* | - |
dc.subject.MESH | Dexamethasone/pharmacology | - |
dc.subject.MESH | Diet/adverse effects | - |
dc.subject.MESH | Glucocorticoids/adverse effects* | - |
dc.subject.MESH | Glucocorticoids/pharmacology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Obesity/chemically induced* | - |
dc.subject.MESH | Obesity/genetics | - |
dc.subject.MESH | Obesity/metabolism | - |
dc.subject.MESH | Obesity/pathology | - |
dc.subject.MESH | ras Proteins/genetics | - |
dc.subject.MESH | ras Proteins/metabolism* | - |
dc.title | Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Jiyoung Y. Cha | - |
dc.contributor.googleauthor | Hyo Jung Kim | - |
dc.contributor.googleauthor | Jung Hwan Yu | - |
dc.contributor.googleauthor | Jing Xu | - |
dc.contributor.googleauthor | Daham Kim | - |
dc.contributor.googleauthor | Bindu D. Paul | - |
dc.contributor.googleauthor | Hyeonjin Choi | - |
dc.contributor.googleauthor | Seyun Kim | - |
dc.contributor.googleauthor | Yoo Jeong Lee | - |
dc.contributor.googleauthor | Gary P. Ho | - |
dc.contributor.googleauthor | Feng Rao | - |
dc.contributor.googleauthor | Solomon H. Snyder | - |
dc.contributor.googleauthor | Jae-woo Kim | - |
dc.identifier.doi | 10.1073/pnas.1320454110 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00865 | - |
dc.contributor.localId | A01204 | - |
dc.relation.journalcode | J02550 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.pmid | 24297897 | - |
dc.identifier.url | http://www.pnas.org/content/110/51/20575.long | - |
dc.subject.keyword | Cushing disease | - |
dc.subject.keyword | cyclic AMP | - |
dc.subject.keyword | insulin | - |
dc.subject.keyword | nitric oxide | - |
dc.contributor.alternativeName | Kim, Jae Woo | - |
dc.contributor.alternativeName | Kim, Hyo Jung | - |
dc.contributor.affiliatedAuthor | Kim, Jae Woo | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 110 | - |
dc.citation.number | 51 | - |
dc.citation.startPage | 20575 | - |
dc.citation.endPage | 20580 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.110(51) : 20575-20580, 2013 | - |
dc.identifier.rimsid | 33598 | - |
dc.type.rims | ART | - |
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