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Effect of alendronate on bone remodeling around implant in the rat

Authors
 Ran Park  ;  Jee-Hwan Kim  ;  Hyunmin Choi  ;  Young-Bum Park  ;  Han-Sung Jung  ;  Hong-Seok Moon 
Citation
 JOURNAL OF ADVANCED PROSTHODONTICS, Vol.5(4) : 374-381, 2013 
Journal Title
 JOURNAL OF ADVANCED PROSTHODONTICS 
ISSN
 2005-7806 
Issue Date
2013
Keywords
Alendronate ; Bisphosphonate-related osteonecrosis of the jaw ; Bone remodeling ; Empty lacuna ; Implant ; Jaw
Abstract
PURPOSE: The purpose of this study was to evaluate the effect of alendronates on bone remodeling around titanium implant in the maxilla of rats. MATERIALS AND METHODS: The maxillary first molars were extracted and customized-titanium implants were placed immediately in thirty male Sprague-Dawley rats. The rats were divided into experimental (bisphosphonate) group and control group. At 4 weeks after implantation, the rats in the bisphosphonate group were subcutaneously injected with alendronate three times a week for 6 weeks where as the rats in control group were injected with saline. The rats were sacrificed at 1, 2, 3, 4, or 6 weeks after starting of injection and maxillary bones were collected subsequently. Alveolar bone remodeling around the implants were evaluated by radiographic and histologic analysis. Microarray analysis and immunohistomorphologic analysis were also performed on one rat, sacrificed at 6 weeks after starting of injection, from each group. Statistical analysis was performed using repeated measures analysis of variance and independent t test at a significance level of 5%. RESULTS: There was no statistically significant difference in the bone area (%) around implant between the bisphosphonate group and the control group. However, the amount of empty lacuna was significantly increased in the bisphosphonate group, especially in the rats sacrificed at 4 weeks after starting of injection compared to that of the corresponding control group. The bisphosphonate group showed the same level of TRAP positive cell count, osteocalcin and angiopoietin 1 as the control group. CONCLUSION: Alendronate may not decrease the amount of osteoclast. However, the significantly increased amount of empty lacuna in the bisphosphonate group may explain the suppression of bone remodeling in the bisphosphonate group.
Files in This Item:
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DOI
10.4047/jap.2013.5.4.374
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Science Research Center (구강과학연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jee Hwan(김지환) ORCID logo https://orcid.org/0000-0002-0872-4906
Moon, Hong Seok(문홍석) ORCID logo https://orcid.org/0000-0001-8118-8145
Park, Young Bum(박영범)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Choi, Hyun Min(최현민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88743
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