Cited 32 times in
Comparative Gene-Expression Analysis of the Dental Follicle and Periodontal Ligament in Humans
DC Field | Value | Language |
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dc.contributor.author | 김성오 | - |
dc.contributor.author | 송제선 | - |
dc.contributor.author | 이제호 | - |
dc.contributor.author | 이효설 | - |
dc.contributor.author | 정한성 | - |
dc.contributor.author | 최병재 | - |
dc.date.accessioned | 2014-12-18T09:42:42Z | - |
dc.date.available | 2014-12-18T09:42:42Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88682 | - |
dc.description.abstract | The human dental follicle partially differentiates into the periodontal ligament (PDL), but their biological functions are different. The gene-expression profiles of the dental follicle and PDL were compared using the cDNA microarray technique. Microarray analysis identified 490 genes with a twofold or greater difference in expression, 365 and 125 of which were more abundant in the dental follicle and PDL, respectively. The most strongly expressed genes in the dental follicle were those related to bone development and remodeling (EGFL6, MMP8, FRZB, and NELL1), apoptosis and chemotaxis (Nox4, CXCL13, and CCL2), and tooth and embryo development (WNT2, PAX3, FGF7, AMBN, AMTN, and SLC4A4), while in the PDL it was the tumor-suppressor gene WIF1. Genes related to bone development and remodeling (STMN2, IBSP, BMP8A, BGLAP, ACP5, OPN, BMP3, and TM7SF4) and wound healing (IL1, IL8, MMP3, and MMP9) were also more strongly expressed in the PDL than in the dental follicle. In selected genes, a comparison among cDNA microarray, real-time reverse-transcription polymerase chain reaction, and immunohistochemical staining confirmed similar relative gene expressions. The gene-expression profiles presented here identify candidate genes that may enable differentiation between the dental follicle and PDL. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Differentiation/physiology | - |
dc.subject.MESH | Dental Sac/metabolism* | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Gene Expression Regulation, Developmental/genetics | - |
dc.subject.MESH | Gene Expression Regulation, Developmental/physiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Periodontal Ligament/metabolism* | - |
dc.subject.MESH | Real-Time Polymerase Chain Reaction | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.title | Comparative Gene-Expression Analysis of the Dental Follicle and Periodontal Ligament in Humans | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Pediatric Dentistry (소아치과학) | - |
dc.contributor.googleauthor | Hyo-Seol Lee | - |
dc.contributor.googleauthor | Jongeun Lee | - |
dc.contributor.googleauthor | Seong-Oh Kim | - |
dc.contributor.googleauthor | Je-Seon Song | - |
dc.contributor.googleauthor | Jae-Ho Lee | - |
dc.contributor.googleauthor | Syng-Ill Lee | - |
dc.contributor.googleauthor | Han-Sung Jung | - |
dc.contributor.googleauthor | Byung-Jai Choi | - |
dc.identifier.doi | 10.1371/journal.pone.0084201 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00577 | - |
dc.contributor.localId | A02058 | - |
dc.contributor.localId | A03134 | - |
dc.contributor.localId | A03340 | - |
dc.contributor.localId | A03758 | - |
dc.contributor.localId | A04061 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 24376796 | - |
dc.subject.keyword | Cell Differentiation/physiology | - |
dc.subject.keyword | Dental Sac/metabolism* | - |
dc.subject.keyword | Gene Expression Profiling | - |
dc.subject.keyword | Gene Expression Regulation, Developmental/genetics | - |
dc.subject.keyword | Gene Expression Regulation, Developmental/physiology* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Oligonucleotide Array Sequence Analysis | - |
dc.subject.keyword | Periodontal Ligament/metabolism* | - |
dc.subject.keyword | Real-Time Polymerase Chain Reaction | - |
dc.subject.keyword | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.contributor.alternativeName | Kim, Seong Oh | - |
dc.contributor.alternativeName | Song, Je Seon | - |
dc.contributor.alternativeName | Lee, Jae Ho | - |
dc.contributor.alternativeName | Lee, Hyo Seol | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.alternativeName | Choi, Byung Jai | - |
dc.contributor.affiliatedAuthor | Kim, Seong Oh | - |
dc.contributor.affiliatedAuthor | Song, Je Seon | - |
dc.contributor.affiliatedAuthor | Lee, Jae Ho | - |
dc.contributor.affiliatedAuthor | Lee, Hyo Seol | - |
dc.contributor.affiliatedAuthor | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Choi, Byung Jai | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | e84201 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.8(12) : e84201, 2013 | - |
dc.identifier.rimsid | 33406 | - |
dc.type.rims | ART | - |
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