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Perfusion Parameters of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Patients with Rectal Cancer: Correlation with Microvascular Density and Vascular Endothelial Growth Factor Expression

 Yeo-Eun Kim  ;  Joon Seok Lim  ;  Junjeong Choi  ;  Daehong Kim  ;  Sungmin Myoung  ;  Myeong-Jin Kim  ;  Ki Whang Kim 
 KOREAN JOURNAL OF RADIOLOGY, Vol.14(6) : 878-885, 2013 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/biosynthesis ; Contrast Media* ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Neoplasm Staging ; Neovascularization, Pathologic/diagnosis ; Neovascularization, Pathologic/metabolism ; Rectal Neoplasms/blood supply ; Rectal Neoplasms/diagnosis* ; Rectal Neoplasms/metabolism ; Retrospective Studies ; Vascular Endothelial Growth Factor A/biosynthesis*
Dynamic contrast-enhanced magnetic resonance imaging ; MVD ; Perfusion ; Rectal cancer ; VEGF
OBJECTIVE: To determine whether quantitative perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) correlate with immunohistochemical markers of angiogenesis in rectal cancer. MATERIALS AND METHODS: Preoperative DCE-MRI was performed in 63 patients with rectal adenocarcinoma. Transendothelial volume transfer (K(trans) ) and fractional volume of the extravascular-extracellular space (Ve) were measured by Interactive Data Language software in rectal cancer. After surgery, microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression scores were determined using immunohistochemical staining of rectal cancer specimens. Perfusion parameters (K(trans) , Ve) of DCE-MRI in rectal cancer were found to be correlated with MVD and VEGF expression scores by Spearman's rank coefficient analysis. T stage and N stage (negative or positive) were correlated with perfusion parameters and MVD. RESULTS: Significant correlation was not found between any DCE-MRI perfusion parameters and MVD (rs = -0.056 and p = 0.662 for K(trans) ; rs = -0.103 and p = 0.416 for Ve), or between any DCE-MRI perfusion parameters and the VEGF expression score (rs = -0.042, p = 0.741 for K(trans) ; r = 0.086, p = 0.497 for Ve) in rectal cancer. TN stage showed no significant correlation with perfusion parameters or MVD (p > 0.05 for all). CONCLUSION: DCE-MRI perfusion parameters, K(trans) and Ve, correlated poorly with MVD and VEGF expression scores in rectal cancer, suggesting that these parameters do not simply denote static histological vascular properties.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Lim, Joon Seok(임준석) ORCID logo https://orcid.org/0000-0002-0334-5042
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