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HIV antiretroviral resistance mutations among antiretroviral treatment-naive and -experienced patients in South Korea

Authors
 Su Jin Jeong ; Nam Su Ku ; Sun Bean Kim ; Jae Kyoung Kim ; Hea Won Ann ; Heun Choi ; Dong Hyun Oh ; Yong Chan Kim ; Jin Young Ahn ; Je Eun Song ; Min Hyung Kim ; Jun Yong Choi ; June Myung Kim ; Young Goo Song ; Sang Hoon Han 
Citation
 AIDS Research and Human Retroviruses, Vol.29(12) : 1617~1620, 2013 
Journal Title
 AIDS Research and Human Retroviruses 
ISSN
 0889-2229 
Issue Date
2013
Abstract
The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88661
DOI
10.1089/aid.2013.0184
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://online.liebertpub.com/doi/abs/10.1089/aid.2013.0184
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