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HIV antiretroviral resistance mutations among antiretroviral treatment-naive and -experienced patients in South Korea

Authors
 Min Hyung Kim  ;  Je Eun Song  ;  Jin Young Ahn  ;  Yong Chan Kim  ;  Dong Hyun Oh  ;  Heun Choi  ;  Hea Won Ann  ;  Jae Kyoung Kim  ;  Sun Bean Kim  ;  Su Jin Jeong  ;  Nam Su Ku  ;  Sang Hoon Han  ;  Young Goo Song  ;  June Myung Kim  ;  Jun Yong Choi 
Citation
 AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol.29(12) : 1617-1620, 2013 
Journal Title
AIDS RESEARCH AND HUMAN RETROVIRUSES
ISSN
 0889-2229 
Issue Date
2013
MeSH
Adult ; Anti-HIV Agents/therapeutic use* ; Drug Resistance, Viral/genetics* ; Female ; HIV Infections/drug therapy* ; Humans ; Male ; Middle Aged ; Mutation* ; Republic of Korea
Keywords
Adult ; Anti-HIV Agents/therapeutic use* ; Drug Resistance, Viral/genetics* ; Female ; HIV Infections/drug therapy* ; Humans ; Male ; Middle Aged ; Mutation* ; Republic of Korea
Abstract
The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea
Full Text
http://online.liebertpub.com/doi/abs/10.1089/aid.2013.0184
DOI
10.1089/aid.2013.0184
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Min Hyung(김민형)
Kim, Sun Bean(김선빈)
Kim, Yong Chan(김용찬)
Kim, Jae Kyoung(김재경)
Kim, June Myung(김준명)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Song, Je Eun(송제은)
Ahn, Jin Young(안진영) ORCID logo https://orcid.org/0000-0002-3740-2826
Ann, Hea Won(안혜원)
Oh, Dong Hyun(오동현)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Heun(최흔) ORCID logo https://orcid.org/0000-0002-9622-9381
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88661
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