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HIV antiretroviral resistance mutations among antiretroviral treatment-naive and -experienced patients in South Korea

 Min Hyung Kim  ;  Je Eun Song  ;  Jin Young Ahn  ;  Yong Chan Kim  ;  Dong Hyun Oh  ;  Heun Choi  ;  Hea Won Ann  ;  Jae Kyoung Kim  ;  Sun Bean Kim  ;  Su Jin Jeong  ;  Nam Su Ku  ;  Sang Hoon Han  ;  Young Goo Song  ;  June Myung Kim  ;  Jun Yong Choi 
 AIDS Research and Human Retroviruses, Vol.29(12) : 1617-1620, 2013 
Journal Title
 AIDS Research and Human Retroviruses 
Issue Date
The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
구남수(Ku, Nam Su) ORCID logo https://orcid.org/0000-0002-9717-4327
김민형(Kim, Min Hyung)
김선빈(Kim, Sun Bean)
김용찬(Kim, Yong Chan)
김재경(Kim, Jae Kyoung)
김준명(Kim, June Myung)
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
송제은(Song, Je Eun)
안진영(Ahn, Jin Young) ORCID logo https://orcid.org/0000-0002-3740-2826
안혜원(Ann, Hea Won)
오동현(Oh, Dong Hyun)
정수진(Jeong, Su Jin) ORCID logo https://orcid.org/0000-0003-4025-4542
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
최흔(Choi, Heun) ORCID logo https://orcid.org/0000-0002-9622-9381
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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