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HIV antiretroviral resistance mutations among antiretroviral treatment-naive and -experienced patients in South Korea

Authors
 Min Hyung Kim  ;  Je Eun Song  ;  Jin Young Ahn  ;  Yong Chan Kim  ;  Dong Hyun Oh  ;  Heun Choi  ;  Hea Won Ann  ;  Jae Kyoung Kim  ;  Sun Bean Kim  ;  Su Jin Jeong  ;  Nam Su Ku  ;  Sang Hoon Han  ;  Young Goo Song  ;  June Myung Kim  ;  Jun Yong Choi 
Citation
 AIDS Research and Human Retroviruses, Vol.29(12) : 1617-1620, 2013 
Journal Title
 AIDS Research and Human Retroviruses 
ISSN
 0889-2229 
Issue Date
2013
Abstract
The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea
Full Text
http://online.liebertpub.com/doi/abs/10.1089/aid.2013.0184
DOI
10.1089/aid.2013.0184
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
구남수(Ku, Nam Su) ORCID logo https://orcid.org/0000-0002-9717-4327
김민형(Kim, Min Hyung)
김선빈(Kim, Sun Bean)
김용찬(Kim, Yong Chan)
김재경(Kim, Jae Kyoung)
김준명(Kim, June Myung)
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
송제은(Song, Je Eun)
안진영(Ahn, Jin Young) ORCID logo https://orcid.org/0000-0002-3740-2826
안혜원(Ann, Hea Won)
오동현(Oh, Dong Hyun)
정수진(Jeong, Su Jin) ORCID logo https://orcid.org/0000-0003-4025-4542
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
최흔(Choi, Heun) ORCID logo https://orcid.org/0000-0002-9622-9381
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88661
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