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Clinical features of supervoiders who suffer from lower urinary tract symptoms: a propensity score-matching study

 Joo Yong Lee  ;  Yoon Soo Hah  ;  Dae Hun Lee  ;  Woo Jin Bang  ;  Won Sik Ham  ;  Seung Wook Lee  ;  Kang Su Cho 
 WORLD JOURNAL OF UROLOGY, Vol.31(6) : 1463-1468, 2013 
Journal Title
Issue Date
Adult ; Aged ; Case-Control Studies ; Comorbidity ; Humans ; Logistic Models ; Lower Urinary Tract Symptoms/epidemiology ; Lower Urinary Tract Symptoms/physiopathology* ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Prostatic Hyperplasia/epidemiology ; Prostatic Hyperplasia/physiopathology ; Retrospective Studies ; Urinary Bladder, Overactive/epidemiology ; Urinary Bladder, Overactive/physiopathology* ; Urination Disorders/epidemiology ; Urination Disorders/physiopathology*
Lower urinary tract symptoms ; Urinary bladder ; Overactive ; Urinary incontinence ; Urge
BACKGROUND: Systematic nodal dissection (SND) is regarded as a core component of lung cancer surgery. However, there has been a concern on the increased morbidity associated with SND. This study was performed to investigate whether or not SND induces significant immune response. METHODS: Sixteen dogs were divided into two groups; group 1 (n = 8) underwent thoracotomy only, and group 2 (n = 8) underwent SND after thoracotomy. We compared interleukin-6 (IL-6) levels in serum, pleural lavage fluid and lung supernatant at the time of thoracotomy (T0) and at 2 h(T1) after thoracotomy (group 1) or SND (group 2). Severity of inflammation and IL-6 expression in lung tissue were evaluated in a semi-quantitative manner. RESULTS: The operative results were comparable. IL-6 was not detected in serum in either group. IL-6 in pleural lavage fluid marginally increased from 4.75 ± 3.74 pg/mL at T0 to 19.75 ± 8.67 pg/mL at T1 in group 1 (P = 0.112), and from 7.75 ± 5.35 pg/mL to 17.72 ± 8.58 pg/mL in group 2 (P = 0.068). IL-6 in lung supernatant increased from 0.36 ± 0.14 pg/mL/mg to 1.15 ± 0.17 pg/mL/mg in group 1 (P = 0.003), and from 0.25 ± 0.08 pg/mL/mg to 0.82 ± 0.17 pg/mL/mg in group 2 (P = 0.001). However, the degree of increase in IL-6 in pleural lavage fluid and lung supernatant were not different between two groups (P = 0.421 and P = 0.448). There was no difference in severity of inflammation and IL-6 expression between groups. CONCLUSIONS: SND did not increase IL-6 in pleural lavage fluid and lung supernatant. This result suggests that SND could be routinely performed in lung cancer surgery without increasing the significant inflammatory response.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Bang, Woo Jin(방우진)
Lee, Seung Wook(이승욱)
Lee, Joo Yong(이주용) ORCID logo https://orcid.org/0000-0002-3470-1767
Cho, Kang Su(조강수) ORCID logo https://orcid.org/0000-0002-3500-8833
Ham, Won Sik(함원식) ORCID logo https://orcid.org/0000-0003-2246-8838
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