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Anti-death strategies against oxidative stress in grafted mesenchymal stem cells

 Woochul Chang  ;  Byeong-Wook Song  ;  Jae-Youn Moon  ;  Min-Ji Cha  ;  Onju Ham  ;  Se-Yeon Lee  ;  Eunmi Choi  ;  Eunhyun Choi   ;  Ki-Chul Hwang 
 Histology and Histopathology, Vol.28(12) : 1529-1536, 2013 
Journal Title
 Histology and Histopathology 
Issue Date
Anoikis/physiology* ; Humans ; Mesenchymal Stem Cell Transplantation* ; Mesenchymal Stromal Cells/physiology ; Oxidative Stress/physiology* ; Reactive Oxygen Species/metabolism
Mesenchymal stem cells ; Reactive oxygen species ; Anoikis ; Myocardial infarction
Mesenchymal stem cells (MSCs) possess the potential for use in cell-based therapy for repair of myocardial injury. The therapeutic potential of MSCs is based on the capacity of MSCs to differentiate into cardiac tissue and release paracrine factors. However, a major problem in the clinical application of MSC-based therapy is the poor viability of transplanted MSCs at the site of graft due to harsh microenvironment conditions, such as ischemia and/or anoikis. Ischemia after myocardial infarction (MI) and interaction of MSCs with their niche is associated with increased production of reactive oxygen species (ROS). ROS hinder cell adhesion and induce detachment of cells, which induces anoikis signals in implanted MSCs. Therefore, strategies to regulate oxidative stress following the implantation of MSCs are therapeutically attractive. In this review, we first describe ROS as a major obstacle in MSC-based therapy and focus on manipulation of implanted MSCs to reduce ROS-mediated anoikis.
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5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Lee, Se Yeon(이세연)
Choi, Eun Mi(최은미)
Choi, Eun Hyun(최은현)
Ham, On Ju(함온주)
Hwang, Ki Chul(황기철)
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