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신생아 저산소성 허혈성 뇌손상에서 신경줄기세포의 치료적 적용

Other Titles
 Therapeutic Application of Neural Stem Cells for Neonatal Hypoxic-Ischemic Brain Injury 
 박국인  ;  구교연  ;  정광수  ;  김미리  ;  김일선  ;  윤석환  ;  이일신  ;  신정은  ;  유하양  ;  은호선  ;  김정은  ;  남궁란  ;  이철 
 Neonatal Medicine, Vol.20(3) : 343-353, 2013 
Journal Title
 Neonatal Medicine 
Issue Date
Neural stem cells (NSCs) are characterized by a capacity for self-renewal, differentiation into multiple neural cell lineages, and migration toward damaged sites in the central nervous system (CNS). NSCs expanded in culture could be implanted into the brain where they integrate into host neural circuitry and stably express foreign genes. It hence appears that transplantation of NSCs has been proposed as a promising therapeutic strategy in neurological disorders. During hypoxic-ischemic (HI) brain injury, factors are transiently elaborated to which NSCs respond by migrating to degenerating regions and differentiating towards replacement of dying neural cells. In addition, NSCs serve as vehicles for gene delivery and appear capable of simultaneous neural cell replacement and gene therapy (e.g. with factors that might enhance neuronal differentiation, neurites outgrowth, proper connectivity, neuroprotection, and/or immunomodulatory substances). When combined with certain synthetic biomaterials, NSCs may be even more effective in 'engineering' the damaged CNS towards reconstitution. Human NSCs were isolated from the forebrain of an aborted fetus at 13 weeks of gestation and were grown as neurospheres in cultures. After the characterization of human NSCs in preclinical testing and the approval of the IRB, a clinical trial of the transplantation of human NSCs into patients with severe perinatal HI brain injury has been performed. The existing data from these clinical trials have shown to be safe, well tolerated, and of neurologically-some benefits. Therefore, long-term and large scale multicenter clinical study is required to determine its precise therapeutic effect and safety.
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1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Clinical Genetics (임상유전학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
구교연(Goo, Kyo Yeon)
김미리(Kim, Mi Ri)
김일선(Kim, Il-Sun) ORCID logo https://orcid.org/0000-0003-4033-4323
김정은(Kim, Jeong Eun)
남궁란(Namgung, Ran) ORCID logo https://orcid.org/0000-0001-7182-9535
박국인(Park, Kook In) ORCID logo https://orcid.org/0000-0001-8499-9293
유하양(Yu, Ha Yang)
윤석환(Yun, Seok Hwan)
은호선(Eun, Ho Seon) ORCID logo https://orcid.org/0000-0001-7212-0341
이일신(Lee, Il Shin)
이철(Lee, Chul)
정광수(Jung, Kwang Soo) ORCID logo https://orcid.org/0000-0001-7365-7247
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