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Association between CDH13 Variants and Cardiometabolic and Vascular Phenotypes in a Korean Population

Authors
 Ji Hyun Lee  ;  Dong-Jik Shin  ;  Sungha Park  ;  Seok-Min Kang  ;  Yangsoo Jang  ;  Sang-Hak Lee 
Citation
 Yonsei Medical Journal, Vol.54(6) : 1305-1312, 2013 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2013
MeSH
Adiponectin/genetics ; Asian Continental Ancestry Group ; Atherosclerosis/epidemiology ; Atherosclerosis/genetics ; Blood Glucose/metabolism ; Cadherins/genetics* ; Cholesterol/blood ; Female ; Humans ; Hypertension/epidemiology ; Hypertension/genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics
Keywords
CDH13 protein ; atherosclerosis ; cholesterol ; glucose ; human ; hypertension
Abstract
PURPOSE: Although some CDH13 single nucleotide polymorphisms (SNPs) have been shown to be determinants of blood adiponectin levels, the clinical implications of CDH13 variants are not yet completely understood. The purpose of this study was to evaluate the effects of SNPs of CDH13 on metabolic and vascular phenotypes. MATERIALS AND METHODS: We included 238 hypertensive subjects and 260 age- and sex-matched controls. Seven tagging-SNPs were identified in the CDH13 gene by whole gene sequencing. The association between these SNP variants and the risk of hypertension, metabolic traits, and carotid intima-media thickness (IMT) was examined. RESULTS: Minor allele carriers of rs12444338 had a lower risk of hypertension, but the association turned out just marginal after adjusting confoudners. Blood glucose levels were higher in the minor allele carriers of c.1407C>T (p=0.01), whereas low-density lipoprotein-cholesterol levels were greater in those of rs6565105 (p=0.02). The minor allele of rs1048612 was associated with a higher body mass index (p=0.01). In addition, the mean carotid IMT was significantly associated with rs12444338 (p=0.02) and rs1048612 (p=0.02). CONCLUSION: These results provide evidence that CDH13 variants are associated with metabolic traits and carotid atherosclerosis in Koreans. This study shows the multifaceted effects of CDH13 variants on cardiometabolic risk.
Files in This Item:
T201303662.pdf Download
DOI
10.3349/ymj.2013.54.6.1305
Appears in Collections:
5. Research Institutes (연구소) > Research Center for Human Natural Defense System (생체방어연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Lee, Ji Hyun(이지현)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88271
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