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A comparison of the predicted risk for cardiovascular disease between HIV-infected and uninfected persons in Korea.

Authors
 Sun Bean Kim  ;  Yong Chan Kim  ;  Min Hyung Kim  ;  Je Eun Song  ;  Dong Hyun Oh  ;  Jin Young Ahn  ;  Nam Su Ku  ;  Hye-won Kim  ;  Su Jin Jeong  ;  Sang Hoon Han  ;  Young Goo Song  ;  Jun Yong Choi  ;  June Myung Kim 
Citation
 SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, Vol.45(11) : 855-862, 2013 
Journal Title
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
ISSN
 0036-5548 
Issue Date
2013
MeSH
Adult ; Antiretroviral Therapy, Highly Active ; Cardiovascular Diseases/epidemiology* ; Case-Control Studies ; Cross-Sectional Studies ; Female ; HIV Infections/complications* ; HIV Infections/drug therapy ; Humans ; Male ; Middle Aged ; Republic of Korea/epidemiology ; Risk Assessment
Keywords
Framingham risk score ; HIV ; HAART ; healthy control group
Abstract
Background: The introduction of highly active antiretroviral therapy (HAART) has extended the life expectancy of persons infected with the human immunodeficiency virus type 1 (HIV-1). However, cardiovascular disease (CVD) is currently an increasing concern for HIV-infected persons. Methods: We conducted a cross-sectional case–control study to evaluate and compare the 10-y cardiovascular risk of HIV-infected Koreans who had been receiving HAART for over 6 months and age- and sex-matched uninfected persons who visited a health promotion center, by calculating Framingham risk scores (FRS). Results: The average 10-y risk for cardiovascular events (FRS) was 7.07% (2–45) in the HIV group and 6.87% (1–37) in the control group (p = 0.77), corresponding to the very low risk group. Among HIV patients, the FRS was above 10% (low to moderate cardiovascular risk) in 19.9% of the patients, and above 20% (high risk) in 1.7% of the patients. In the healthy control group, the FRS was above 10% in 16.8% and above 20% in 2.7% (p = 0.57). The FRS was not significantly different for HIV-infected patients treated with protease inhibitor (PI)-based HAART and those treated with non-nucleoside reverse transcriptase inhibitor (NNRTI)-based HAART (7.26 ± 6.3 and 6.81 ± 4.4, respectively, p = 0.69). Conclusions: The predicted cardiovascular risk of HIV-infected Koreans on HAART by FRS equation was low and similar to that of age- and sex-matched healthy control persons. However, the possibility remains that actual cardiovascular events could be underestimated. The next step for predicting the cardiovascular risk is to calculate the Data Collection of Adverse Events of Anti-HIV Drugs (D:A:D) equation risks.
Full Text
http://informahealthcare.com/doi/abs/10.3109/00365548.2013.813064
DOI
10.3109/00365548.2013.813064
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Min Hyung(김민형)
Kim, Sun Bean(김선빈)
Kim, Yong Chan(김용찬)
Kim, June Myung(김준명)
Kim, Hye Won(김혜원)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Song, Je Eun(송제은)
Ahn, Jin Young(안진영) ORCID logo https://orcid.org/0000-0002-3740-2826
Oh, Dong Hyun(오동현)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88266
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