6 337

Cited 16 times in

The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant

Authors
 Jong-Eun Kim  ;  Seong-Su Kang  ;  Kyung-Hee Choi  ;  June-Sung Shim  ;  Chang-Mo Jeong  ;  Sang-Wan Shin  ;  Jung-Bo Huh 
Citation
 ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, Vol.115(6) : 24-31, 2013 
Journal Title
 ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 
ISSN
 2212-4403 
Issue Date
2013
MeSH
Alveolar Process/physiopathology ; Alveolar Process/surgery* ; Analysis of Variance ; Animals ; Bone Morphogenetic Protein 2/pharmacology* ; Bone Regeneration/drug effects* ; Coated Materials, Biocompatible/pharmacology* ; Dental Implantation, Endosseous/methods* ; Dental Implants* ; Dogs ; Male ; Vascular Endothelial Growth Factor A/pharmacology*
Keywords
Alveolar Process/physiopathology ; Alveolar Process/surgery* ; Analysis of Variance ; Animals ; Bone Morphogenetic Protein 2/pharmacology* ; Bone Regeneration/drug effects* ; Coated Materials, Biocompatible/pharmacology* ; Dental Implantation, Endosseous/methods* ; Dental Implants* ; Dogs ; Male ; Vascular Endothelial Growth Factor A/pharmacology*
Abstract
OBJECTIVES: The aim of this study was to evaluate the effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors (rhVEGFs) on vertical bone regeneration in the marginal portion of the peri-implant. STUDY DESIGN: Supra-alveolar defects were created in 3 male beagle dogs. Each animal received 8 implants that were either coated with a single growth factor (rhBMP-2) or combined growth factors (rhBMP-2 + rhVEGF), or an anodized implant (the control group). The amount of the vertical bone regeneration, the bone-implant contact, and the intrathread bone density were investigated using histomorphometric analysis at 8 weeks. RESULTS: The bone morphogenetic protein (BMP) group and the BMP-VEGF group showed vertical alveolar bone regeneration and enhanced bone-implant contact in the microthread compared with the control group (P < .05). CONCLUSIONS: Anodized implants coated with rhBMP-2 and rhBMP - 2 + rhVEGF can induce vertical alveolar bone regeneration, but the combined effect of rhBMP-2 and rhVEGF was not verified.
Full Text
http://www.sciencedirect.com/science/article/pii/S2212440312001745
DOI
10.1016/j.oooo.2011.10.040
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Eun(김종은) ORCID logo https://orcid.org/0000-0002-7834-2524
Shim, June Sung(심준성) ORCID logo https://orcid.org/0000-0003-1428-0122
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88221
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links