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Aptamer-modified magnetic nanoprobe for molecular MR imaging of VEGFR2 on angiogenic vasculature

DC FieldValueLanguage
dc.contributor.author서진석-
dc.contributor.author양재문-
dc.contributor.author허용민-
dc.date.accessioned2014-12-18T09:23:46Z-
dc.date.available2014-12-18T09:23:46Z-
dc.date.issued2013-
dc.identifier.issn1931-7573-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88091-
dc.description.abstractNucleic acid-based aptamers have been developed for the specific delivery of diagnostic nanoprobes. Here, we introduce a new class of smart imaging nanoprobe, which is based on hybridization of a magnetic nanocrystal with a specific aptamer for specific detection of the angiogenic vasculature of glioblastoma via magnetic resonance (MR) imaging. The magnetic nanocrystal imaging core was synthesized using the thermal decomposition method and enveloped by carboxyl polysorbate 80 for water solubilization and conjugation of the targeting moiety. Subsequently, the surface of the carboxylated magnetic nanocrystal was modified with amine-functionalized aptamers that specifically bind to the vascular growth factor receptor 2 (VEGFR2) that is overexpressed on angiogenic vessels. To assess the targeted imaging potential of the aptamer-conjugated magnetic nanocrystal for VEGFR2 markers, the magnetic properties and MR imaging sensitivity were investigated using the orthotopic glioblastoma mouse model. In in vivo tests, the aptamer-conjugated magnetic nanocrystal effectively targeted VEGFR2 and demonstrated excellent MR imaging sensitivity with no cytotoxicity.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfNANOSCALE RESEARCH LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAptamer-modified magnetic nanoprobe for molecular MR imaging of VEGFR2 on angiogenic vasculature-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorBongjune Kim-
dc.contributor.googleauthorJaemoon Yang-
dc.contributor.googleauthorMyeonghwan Hwang-
dc.contributor.googleauthorJihye Choi-
dc.contributor.googleauthorHyun-Ouk Kim-
dc.contributor.googleauthorEunji Jang-
dc.contributor.googleauthorJung Hwan Lee-
dc.contributor.googleauthorSung-Ho Ryu-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorYong-Min Huh-
dc.contributor.googleauthorSeungjoo Haam-
dc.identifier.doi10.1186/1556-276X-8-399-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01916-
dc.contributor.localIdA04359-
dc.contributor.localIdA02315-
dc.relation.journalcodeJ02286-
dc.identifier.eissn1556-276X-
dc.identifier.pmid24066922-
dc.subject.keywordMagnetic nanocrystal-
dc.subject.keywordAptamer-
dc.subject.keywordVEGFR2-
dc.subject.keywordAngiogenesis-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordMolecular imaging-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameYang, Jae Moon-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.contributor.affiliatedAuthorYang, Jae Moon-
dc.rights.accessRightsfree-
dc.citation.volume8-
dc.citation.number1-
dc.citation.startPage399-
dc.identifier.bibliographicCitationNANOSCALE RESEARCH LETTERS, Vol.8(1) : 399, 2013-
dc.identifier.rimsid33045-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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