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Evaluation of 18F-FDG Excretion Patterns in Malignant Obstructive Uropathy

Authors
 Cho, Arthur  ;  Chung, Yong Eun  ;  Lee, Jae-hoon  ;  Yun, Mijin  ;  Lee, Jong Doo  ;  Kang, Won Jun 
Citation
 CLINICAL NUCLEAR MEDICINE, Vol.38(9) : 695-702, 2013 
Journal Title
 CLINICAL NUCLEAR MEDICINE 
ISSN
 0363-9762 
Issue Date
2013
MeSH
Demography ; Female ; Fluorodeoxyglucose F18* ; Humans ; Hydronephrosis/diagnostic imaging* ; Kidney/diagnostic imaging* ; Logistic Models ; Male ; Middle Aged ; Positron-Emission Tomography ; Stents ; Tomography, X-Ray Computed ; Treatment Outcome
Keywords
ureteral obstruction ; hydronephrosis ; 18F-FDG ; ureteral stent ; integrated PET/CT
Abstract
OBJECTIVES: This study aims to evaluate whether (18)F-FDG excretion patterns reflect renal function in malignant obstructive uropathy and to evaluate if these patterns predict internal ureteral stent success. METHODS: One hundred twelve patients who underwent PET/CT for abdominal tumors and displayed hydronephrosis on CT and 59 patients who underwent PET/CT for cancer screening were included in a retrospective study. Hydronephrosis was graded by initial CT and correlated with visual analysis of (18)F-FDG renal parenchymal uptake and excretion patterns. Stent insertion was performed for 84 patients after PET. Follow-up CT was reviewed for hydronephrosis improvement. RESULTS: There were 4 PET patterns in obstructive hydronephrosis which correlated linearly with hydronephrosis severity and serum creatinine levels. Patients with no parenchymal retention and renal excretion (PET pattern 1) showed 97% (28/29) hydronephrosis improvement after stent insertion, and patients with no parenchymal retention and no renal excretion showed 0% (0/9) hydronephrosis improvement after stent insertion. Multivariate analysis showed creatinine levels and PET pattern predicted stent success, but CT hydronephrosis did not. CONCLUSIONS: There are 4 PET patterns of obstructive hydronephrosis which correlated with hydronephrosis grade and creatinine levels. Some of these PET patterns can be useful in the prediction of hydronephrosis improvement after stent insertion. Recognition of these patterns in obstructive hydronephrosis may be helpful in improving patient prognosis and quality of life.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003072-201309000-00005&LSLINK=80&D=ovft
DOI
10.1097/RLU.0b013e31829b2012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Jun(강원준) ORCID logo https://orcid.org/0000-0002-2107-8160
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Lee, Jong Doo(이종두)
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
Cho, Arthur Eung Hyuck(조응혁) ORCID logo https://orcid.org/0000-0001-8670-2473
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88061
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