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Age-related changes in liver, kidney, and spleen stiffness in healthy children measured with acoustic radiation force impulse imaging

 Mi-Jung Lee  ;  Myung-Joon Kim  ;  Kyung Hwa Han  ;  Choon Sik Yoon 
 EUROPEAN JOURNAL OF RADIOLOGY, Vol.82(6) : 290-294, 2013 
Journal Title
Issue Date
Adolescent ; Age Distribution ; Aging/physiology* ; Child ; Child, Preschool ; Elastic Modulus/physiology* ; Elasticity Imaging Techniques/statistics & numerical data* ; Female ; Healthy Volunteers/statistics & numerical data* ; Humans ; Kidney/diagnostic imaging ; Kidney/physiology* ; Liver/diagnostic imaging ; Liver/physiology* ; Male ; Organ Specificity/physiology ; Reproducibility of Results ; Republic of Korea/epidemiology ; Sensitivity and Specificity ; Spleen/diagnostic imaging ; Spleen/physiology*
Acoustic radiation force impulse-imaging ; Liver ; Kidney ; Spleen ; Child
OBJECTIVES: To evaluate the feasibility and age-related changes of shear wave velocity (SWV) in normal livers, kidneys, and spleens of children using acoustic radiation force impulse (ARFI) imaging. MATERIALS AND METHODS: Healthy pediatric volunteers prospectively underwent abdominal ultrasonography and ARFI. The subjects were divided into three groups according to age: group 1: <5 years old; group 2: 5-10 years old; and group 3: >10 years old. The SWV was measured using a 4-9 MHz linear probe for group 1 and a 1-4 MHz convex probe for groups 2 and 3. Three valid SWV measurements were acquired for each organ. RESULTS: Two hundred and two children (92 male, 110 female) with an average age of 8.1 years (± 4.7) were included in this study and had a successful measurement rate of 97% (196/202). The mean SWVs were 1.12 m/s for the liver, 2.19 m/s for the right kidney, 2.33 m/s for the left kidney, and 2.25 m/s for the spleen. The SWVs for the right and left kidneys, and the spleen showed age-related changes in all children (p<0.001). And the SWVs for the kidneys increased with age in group 1, and those for the liver changed with age in group 3. CONCLUSIONS: ARFI measurements are feasible for solid abdominal organs in children using high or low frequency probes. The mean ARFI SWV for the kidneys increased according to age in children less than 5 years of age and in the liver, it changed with age in children over 10.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Myung Joon(김명준) ORCID logo https://orcid.org/0000-0002-4608-0275
Yoon, Choon Sik(윤춘식) ORCID logo https://orcid.org/0000-0003-2010-6710
Lee, Mi-Jung(이미정) ORCID logo https://orcid.org/0000-0003-3244-9171
Han, Kyung Hwa(한경화)
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