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18F-FDG PET Metabolic Parameters and MRI Perfusion and Diffusion Parameters in Hepatocellular Carcinoma: A Preliminary Study

Authors
 Sung Jun Ahn  ;  Mi-Suk Park  ;  Kyung Ah Kim  ;  Jun Yong Park  ;  InSeong Kim  ;  Won Joon Kang  ;  Seung-Koo Lee  ;  Myeong-Jin Kim 
Citation
 PLoS One, Vol.8(8) : e71571, 2013 
Journal Title
 PLoS One 
ISSN
 1932-6203 
Issue Date
2013
Abstract
OBJECTIVES: Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC), using multimodality imaging such as ¹⁸F-FDG positron emission tomography (PET), dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging(DWI). MATERIALS AND METHODS: Twenty-one patients with advanced HCC underwent ¹⁸F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUV(max)) from ¹⁸F-FDG-PET, variables of the volume transfer constant (K(trans)) from DCE-MRI and apparent diffusion coefficient (ADC) from DWI were obtained for the tumor and their relationships were examined by Spearman's correlation analysis. The influence of portal vein thrombosis on SUV(max) and variables of K(trans) and ADC was evaluated by Mann-Whitney test. RESULTS: SUV(max) showed significant negative correlation with K(trans)(max) (ρ = -0.622, p = 0.002). However, variables of ADC showed no relationship with variables of K(trans) or SUV(max) (p>0.05). Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K(trans) (p>0.05). CONCLUSION: In this study, SUV was shown to be correlated with K(trans) in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.
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DOI
10.1371/journal.pone.0071571
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
강원준(Kang, Won Jun) ORCID logo https://orcid.org/0000-0002-2107-8160
김경아(Kim, Kyung Ah)
김명진(Kim, Myeong Jin) ORCID logo https://orcid.org/0000-0001-7949-5402
박미숙(Park, Mi-Suk) ORCID logo https://orcid.org/0000-0001-5817-2444
박준용(Park, Jun Yong) ORCID logo https://orcid.org/0000-0001-6324-2224
안성준(Ahn, Sung Jun) ORCID logo https://orcid.org/0000-0003-0075-2432
이승구(Lee, Seung Koo) ORCID logo https://orcid.org/0000-0001-5646-4072
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87924
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