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Impaired mobilization of bone marrow derived CD34 positive mononuclear cells is related to the recurrence of atrial fibrillation after radiofrequency catheter ablation

Authors
 Jaemin Shim  ;  Jae Hyung Park  ;  Jong Youn Kim  ;  Sook Kyoung Kim  ;  Boyoung Joung  ;  Moon-Hyoung Lee  ;  Young-Hoon Kim  ;  Hui-Nam Pak 
Citation
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.162(3) : 179-183, 2013 
Journal Title
INTERNATIONAL JOURNAL OF CARDIOLOGY
ISSN
 0167-5273 
Issue Date
2013
MeSH
Adult ; Aged ; Antigens, CD34/biosynthesis* ; Atrial Fibrillation/blood* ; Atrial Fibrillation/diagnosis* ; Atrial Fibrillation/epidemiology ; Bone Marrow Cells/metabolism* ; Catheter Ablation/adverse effects* ; Cell Movement/physiology ; Female ; Follow-Up Studies ; Humans ; Leukocytes, Mononuclear/metabolism* ; Male ; Middle Aged ; Recurrence ; Treatment Outcome
Keywords
CD34+ mononuclear cell ; Atrial fibrillation ; Catheter ablation ; Recurrence
Abstract
BACKGROUND:
We have reported previously that non-ischemic titrated cardiac injury by radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) mobilizes bone marrow derived CD34+ mononuclear cells. We hypothesized that the degree of post-RFCA CD34+ cell mobilization affects the clinical outcome of AF ablation.
METHODS AND RESULTS:
Fifty-six patients (39 males, 53 ± 13 years) who underwent electrophysiology study (EPS; n=10) or RFCA of AF (n=46) were included. The peripheral blood CD34+ cell count and multiple serologic markers were evaluated before, immediately after the procedure. Results: 1. The percent increase of CD34+ cells (%ΔCD34+) was significant after RFCA as compared to EPS (p < 0.01). 2. The post-RFCA CD34+ cell count was significantly higher in patients who underwent RF energy delivery ≥80 min than those <80 min (p = 0.024). 3. The %ΔCD34+ was linearly correlated with the plasma level of troponin I (R = 0.38, p < 0.01), but not with the non-ablation procedure time (p = NS). 3. During 30.2 ± 2.7 months follow-up, AF recurred in 37% of patients including early recurrence (34.8%). In contrast, the patients in whom AF recurred received a longer duration of RF energy delivery than those remaining in sinus rhythm (p = 0.04), they were associated with lower %ΔCD34+ (p = 0.02).
CONCLUSION:
CD34+ mononuclear cells were mobilized after catheter ablation by RF energy dose dependent manner, and the duration of RF energy delivery was longer in patients with AF recurrence. However, CD34+ mononuclear cell mobilization was significantly impaired in patients with recurring AF after RFCA.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167527311004773
DOI
10.1016/j.ijcard.2011.05.064
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Jong Youn(김종윤) ORCID logo https://orcid.org/0000-0001-7040-8771
Park, Jae Hyung(박재형)
Pak, Hui Nam(박희남) ORCID logo https://orcid.org/0000-0002-3256-3620
Shim, Jae Min(심재민)
Lee, Moon-Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87878
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