Cited 5 times in
Impaired mobilization of bone marrow derived CD34 positive mononuclear cells is related to the recurrence of atrial fibrillation after radiofrequency catheter ablation
DC Field | Value | Language |
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dc.contributor.author | 정보영 | - |
dc.contributor.author | 김종윤 | - |
dc.contributor.author | 박재형 | - |
dc.contributor.author | 박희남 | - |
dc.contributor.author | 심재민 | - |
dc.contributor.author | 이문형 | - |
dc.date.accessioned | 2014-12-18T09:16:58Z | - |
dc.date.available | 2014-12-18T09:16:58Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87878 | - |
dc.description.abstract | BACKGROUND: We have reported previously that non-ischemic titrated cardiac injury by radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) mobilizes bone marrow derived CD34+ mononuclear cells. We hypothesized that the degree of post-RFCA CD34+ cell mobilization affects the clinical outcome of AF ablation. METHODS AND RESULTS: Fifty-six patients (39 males, 53 ± 13 years) who underwent electrophysiology study (EPS; n=10) or RFCA of AF (n=46) were included. The peripheral blood CD34+ cell count and multiple serologic markers were evaluated before, immediately after the procedure. Results: 1. The percent increase of CD34+ cells (%ΔCD34+) was significant after RFCA as compared to EPS (p < 0.01). 2. The post-RFCA CD34+ cell count was significantly higher in patients who underwent RF energy delivery ≥80 min than those <80 min (p = 0.024). 3. The %ΔCD34+ was linearly correlated with the plasma level of troponin I (R = 0.38, p < 0.01), but not with the non-ablation procedure time (p = NS). 3. During 30.2 ± 2.7 months follow-up, AF recurred in 37% of patients including early recurrence (34.8%). In contrast, the patients in whom AF recurred received a longer duration of RF energy delivery than those remaining in sinus rhythm (p = 0.04), they were associated with lower %ΔCD34+ (p = 0.02). CONCLUSION: CD34+ mononuclear cells were mobilized after catheter ablation by RF energy dose dependent manner, and the duration of RF energy delivery was longer in patients with AF recurrence. However, CD34+ mononuclear cell mobilization was significantly impaired in patients with recurring AF after RFCA. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antigens, CD34/biosynthesis* | - |
dc.subject.MESH | Atrial Fibrillation/blood* | - |
dc.subject.MESH | Atrial Fibrillation/diagnosis* | - |
dc.subject.MESH | Atrial Fibrillation/epidemiology | - |
dc.subject.MESH | Bone Marrow Cells/metabolism* | - |
dc.subject.MESH | Catheter Ablation/adverse effects* | - |
dc.subject.MESH | Cell Movement/physiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukocytes, Mononuclear/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Recurrence | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Impaired mobilization of bone marrow derived CD34 positive mononuclear cells is related to the recurrence of atrial fibrillation after radiofrequency catheter ablation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jaemin Shim | - |
dc.contributor.googleauthor | Jae Hyung Park | - |
dc.contributor.googleauthor | Jong Youn Kim | - |
dc.contributor.googleauthor | Sook Kyoung Kim | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Young-Hoon Kim | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.identifier.doi | 10.1016/j.ijcard.2011.05.064 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03609 | - |
dc.contributor.localId | A00926 | - |
dc.contributor.localId | A01639 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02206 | - |
dc.contributor.localId | A02766 | - |
dc.relation.journalcode | J01093 | - |
dc.identifier.eissn | 1874-1754 | - |
dc.identifier.pmid | 21640411 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0167527311004773 | - |
dc.subject.keyword | CD34+ mononuclear cell | - |
dc.subject.keyword | Atrial fibrillation | - |
dc.subject.keyword | Catheter ablation | - |
dc.subject.keyword | Recurrence | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.alternativeName | Kim, Jong Youn | - |
dc.contributor.alternativeName | Park, Jae Hyung | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Shim, Jae Min | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Kim, Jong Youn | - |
dc.contributor.affiliatedAuthor | Park, Jae Hyung | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Shim, Jae Min | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 162 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 179 | - |
dc.citation.endPage | 183 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.162(3) : 179-183, 2013 | - |
dc.identifier.rimsid | 32586 | - |
dc.type.rims | ART | - |
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