20 89

Cited 0 times in

Epigenetic regulation in the brain after spinal cord injury: A comparative study

 Bit-Na-Ri Park ; Seok Won Kim ; Sung-Hoon Kim ; Young-Hee Lee ; Ji Yong Lee ; Sung-Rae Cho 
 Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.53(6) : 337~341, 2013 
Journal Title
 Journal of Korean Neurosurgical Society (대한신경외과학회지) 
Issue Date
OBJECTIVE: After spinal cord injury (SCI), functional and structural reorganization occurs at multiple levels of brain including motor cortex. However, the underlying mechanism still remains unclear. The current study was performed to investigate the alterations in the expression of the main regulators of neuronal development, survival and death, in the brain following thoracic contusive SCI in a mouse model. METHODS: Eight-week-old female imprinting control region mice (n=60; 30-35 g) were used in this study. We analyzed the expression levels of regulators such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and histone deacetylase (HDAC) 1 in the brain following thoracic contusive SCI. RESULTS: The expression of BDNF levels were elevated significantly compared with control group at 2 weeks after injury (p<0.05). The expression of NGF levels were elevated at 2, 4 weeks compared with control group, but these difference were not significant (p>0.05). The GDNF levels were elevated at 2 week compared with control group, but these differences were not significant (p>0.05). The difference of HDAC1 levels were not significant at 2, 4 and 8 weeks compared with control group (p>0.05). CONCLUSION: These results demonstrate that the upregulation of BDNF may play on important role in brain reorganization after SCI.
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Rehabilitation Medicine
Yonsei Authors
사서에게 알리기
Files in This Item:
RIS (EndNote)
XLS (Excel)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.