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The effect of pulmonary blood flow changes on oxygen-enhanced lung magnetic resonance imaging

Authors
 Hye-Jeong Lee  ;  Jaeseok Park  ;  Jin Hur  ;  Young Jin Kim  ;  Ji Eun Nam  ;  Byoung Wook Choi  ;  Kyu Ok Choe 
Citation
 MAGNETIC RESONANCE IN MEDICINE, Vol.69(6) : 1645-1649, 2013 
Journal Title
 MAGNETIC RESONANCE IN MEDICINE 
ISSN
 0740-3194 
Issue Date
2013
MeSH
Administration, Inhalation ; Animals ; Blood Flow Velocity/physiology ; Contrast Media/administration & dosage ; Lung/anatomy & histology* ; Lung/physiology* ; Magnetic Resonance Angiography/methods* ; Magnetic Resonance Imaging/methods* ; Male ; Oxygen/administration & dosage ; Oxygen/blood* ; Pulmonary Circulation/physiology* ; Rabbits ; Reproducibility of Results ; Sensitivity and Specificity
Keywords
magnetic resonance imaging ; ventilation ; oxygen ; pulmonary function ; pulmonary perfusion
Abstract
In this study, we investigated the effects of changes in pulmonary blood flow on oxygen-enhanced lung magnetic resonance imaging. Increased pulmonary blood flow was produced by intravenous infusion of sildenafil (0.2 mg/kg) in 10 New Zealand white rabbits. Decreased pulmonary blood flow was produced by single subcutaneous injection of monocrotaline (60 mg/kg). A velocity-encoded cine magnetic resonance imaging for pulmonary blood flow and an oxygen-enhanced lung magnetic resonance imaging were performed at baseline, during sildenafil infusion, and after monocrotaline injection. We compared the baseline data to those obtained during sildenafil infusion and after monocrotaline injection for pulmonary blood flow changes and signal intensity enhancement ratios of oxygen-enhanced lung magnetic resonance imaging. Wilcoxon's signed rank test was used for statistical analysis. There was a significant difference between pulmonary blood flow at baseline (418.6±108.9 mL/min) and after sildenafil (491.9±118.0 mL/min; P=0.005) or between pulmonary blood flow at baseline and after monocrotaline administration (356.3±85.8 mL/min; P=0.017). However, there was no significant difference between the signal intensity enhancement ratios at baseline (23.8±11.4%) and after sildenafil (24.0±7.9%; P=0.953) or the signal intensity enhancement ratios at baseline and after monocrotaline administration (22.7±10.3%; P=0.374). Changes in pulmonary blood flow had little effect on the signal intensity enhancement ratio of oxygen-enhanced lung magnetic resonance imaging.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mrm.24388/abstract
DOI
10.1002/mrm.24388
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Nam, Ji Eun(남지은)
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Choe, Kyu Ok(최규옥)
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87686
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