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dTULP, the Drosophila melanogaster Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia

Authors
 Jina Park  ;  Jeongmi Lee  ;  Jaewon Shim  ;  Woongsu Han  ;  Jinu Lee  ;  Yong Chul Bae  ;  Yun Doo Chung  ;  Chul Hoon Kim  ;  Seok Jun Moon 
Citation
 PLoS Genetics, Vol.9(9) : e1003814, 2013 
Journal Title
 PLoS Genetics 
ISSN
 1553-7404 
Issue Date
2013
Abstract
Mechanically gated ion channels convert sound into an electrical signal for the sense of hearing. In Drosophila melanogaster, several transient receptor potential (TRP) channels have been implicated to be involved in this process. TRPN (NompC) and TRPV (Inactive) channels are localized in the distal and proximal ciliary zones of auditory receptor neurons, respectively. This segregated ciliary localization suggests distinct roles in auditory transduction. However, the regulation of this localization is not fully understood. Here we show that the Drosophila Tubby homolog, King tubby (hereafter called dTULP) regulates ciliary localization of TRPs. dTULP-deficient flies show uncoordinated movement and complete loss of sound-evoked action potentials. Inactive and NompC are mislocalized in the cilia of auditory receptor neurons in the dTulp mutants, indicating that dTULP is required for proper cilia membrane protein localization. This is the first demonstration that dTULP regulates TRP channel localization in cilia, and suggests that dTULP is a protein that regulates ciliary neurosensory functions.
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DOI
10.1371/journal.pgen.1003814
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
Park, Ji Na(박지나)
Shim, Jae Won(심재원)
Han, Woong Su(한웅수) ORCID logo https://orcid.org/0000-0002-4250-1124
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87591
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