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The effects of statins on the clinical outcomes of Clostridium difficile infection in hospitalised patients

 S. W. Park  ;  A. R. Choi  ;  H. J. Lee  ;  H. Chung  ;  J. C. Park  ;  S. K. Shin  ;  S. K. Lee  ;  Y. C. Lee  ;  J. E. Kim  ;  H. Lee 
 Alimentary Pharmacology and Therapeutics, Vol.38(6) : 619-627, 2013 
Journal Title
 Alimentary Pharmacology and Therapeutics 
Issue Date
BACKGROUND: An association between exposure to statin drugs and favourable treatment outcomes for various types of infections has been established. AIM: To determine the clinical characteristics and treatment outcomes of Clostridium difficile infection (CDI) among hospitalised patients taking statin drugs. METHODS: The medical records were reviewed for consecutive in-patients with CDI confirmed by positive toxin assay (A or B), C. difficile culture, or the presence of pseudomembrane on endoscopy. Treatment success was defined as the resolution of diarrhoea within 6 days of therapy. The primary end points were assessed by average symptom recovery time and treatment response (success or failure). RESULTS: Among 949 patients, the overall response to metronidazole was 91.9%. The baseline characteristics showed some differences between statin users and statin non-users with respect to mean disease severity score. In the multivariate analysis, successful treatment response was significantly associated with the absence of exposure to proton pump inhibitors (PPIs) (OR = 0.690, 95% CI = 0.513-0.929, P = 0.014) and with exposure to statins (OR = 1.449, 95% CI = 1.015-2.070, P = 0.041). Contrary to the treatment response, univariate and multivariate analyses failed to show that exposure to PPIs or statins affected symptom recovery times. Sixty-day CDI recurrence rates for those patients with statin exposure were significantly lower compared with those patients without statin exposure (3% vs. 7.3%, respectively; RR = 0.393, 95% CI = 0.167-0.926, P = 0.033). CONCLUSION: Prior statin exposure in patients with C. difficile infection is associated with a successful response to treatment.
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1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김지은(Kim, Ji Eun)
박세우(Park, Se Woo)
박준철(Park, Jun Chul) ORCID logo https://orcid.org/0000-0001-8018-0010
신성관(Shin, Sung Kwan)
이상길(Lee, Sang Kil) ORCID logo https://orcid.org/0000-0002-0721-0364
이용찬(Lee, Yong Chan)
이혁(Lee, Hyuk)
이현직(Lee, Hyun Jik)
정현수(Chong, Hyon Su)
최아라(Choi, A Ra)
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