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The effects of statins on the clinical outcomes of Clostridium difficile infection in hospitalised patients

DC FieldValueLanguage
dc.contributor.author이용찬-
dc.contributor.author이혁-
dc.contributor.author이현직-
dc.contributor.author정현수-
dc.contributor.author최아라-
dc.contributor.author김지은-
dc.contributor.author박세우-
dc.contributor.author박준철-
dc.contributor.author신성관-
dc.contributor.author이상길-
dc.date.accessioned2014-12-18T09:07:14Z-
dc.date.available2014-12-18T09:07:14Z-
dc.date.issued2013-
dc.identifier.issn0269-2813-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87572-
dc.description.abstractBACKGROUND: An association between exposure to statin drugs and favourable treatment outcomes for various types of infections has been established. AIM: To determine the clinical characteristics and treatment outcomes of Clostridium difficile infection (CDI) among hospitalised patients taking statin drugs. METHODS: The medical records were reviewed for consecutive in-patients with CDI confirmed by positive toxin assay (A or B), C. difficile culture, or the presence of pseudomembrane on endoscopy. Treatment success was defined as the resolution of diarrhoea within 6 days of therapy. The primary end points were assessed by average symptom recovery time and treatment response (success or failure). RESULTS: Among 949 patients, the overall response to metronidazole was 91.9%. The baseline characteristics showed some differences between statin users and statin non-users with respect to mean disease severity score. In the multivariate analysis, successful treatment response was significantly associated with the absence of exposure to proton pump inhibitors (PPIs) (OR = 0.690, 95% CI = 0.513-0.929, P = 0.014) and with exposure to statins (OR = 1.449, 95% CI = 1.015-2.070, P = 0.041). Contrary to the treatment response, univariate and multivariate analyses failed to show that exposure to PPIs or statins affected symptom recovery times. Sixty-day CDI recurrence rates for those patients with statin exposure were significantly lower compared with those patients without statin exposure (3% vs. 7.3%, respectively; RR = 0.393, 95% CI = 0.167-0.926, P = 0.033). CONCLUSION: Prior statin exposure in patients with C. difficile infection is associated with a successful response to treatment.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfAlimentary Pharmacology and Therapeutics-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAnti-Infective Agents/therapeutic use-
dc.subject.MESHClostridium difficile/isolation & purification*-
dc.subject.MESHDiarrhea/drug therapy-
dc.subject.MESHDiarrhea/etiology-
dc.subject.MESHEnterocolitis, Pseudomembranous/drug therapy*-
dc.subject.MESHFemale-
dc.subject.MESHHospitalization-
dc.subject.MESHHumans-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMetronidazole/therapeutic use-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHProton Pump Inhibitors/therapeutic use*-
dc.subject.MESHTreatment Outcome-
dc.titleThe effects of statins on the clinical outcomes of Clostridium difficile infection in hospitalised patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentMedical Research Center (임상의학연구센터)-
dc.contributor.googleauthorS. W. Park-
dc.contributor.googleauthorA. R. Choi-
dc.contributor.googleauthorH. J. Lee-
dc.contributor.googleauthorH. Chung-
dc.contributor.googleauthorJ. C. Park-
dc.contributor.googleauthorS. K. Shin-
dc.contributor.googleauthorS. K. Lee-
dc.contributor.googleauthorY. C. Lee-
dc.contributor.googleauthorJ. E. Kim-
dc.contributor.googleauthorH. Lee-
dc.identifier.doi10.1111/apt.12439-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02988-
dc.contributor.localIdA03285-
dc.contributor.localIdA03300-
dc.contributor.localIdA03766-
dc.contributor.localIdA04104-
dc.contributor.localIdA01520-
dc.contributor.localIdA01676-
dc.contributor.localIdA02112-
dc.contributor.localIdA02812-
dc.contributor.localIdA00993-
dc.relation.journalcodeJ00061-
dc.identifier.pmid23888883-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/apt.12439/abstract-
dc.subject.keywordAged-
dc.subject.keywordAnti-Infective Agents/therapeutic use-
dc.subject.keywordClostridium difficile/isolation & purification*-
dc.subject.keywordDiarrhea/drug therapy-
dc.subject.keywordDiarrhea/etiology-
dc.subject.keywordEnterocolitis, Pseudomembranous/drug therapy*-
dc.subject.keywordFemale-
dc.subject.keywordHospitalization-
dc.subject.keywordHumans-
dc.subject.keywordHydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use*-
dc.subject.keywordMale-
dc.subject.keywordMetronidazole/therapeutic use-
dc.subject.keywordMiddle Aged-
dc.subject.keywordMultivariate Analysis-
dc.subject.keywordProton Pump Inhibitors/therapeutic use*-
dc.subject.keywordTreatment Outcome-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameLee, Hyuk-
dc.contributor.alternativeNameLee, Hyun Jik-
dc.contributor.alternativeNameChong, Hyon Su-
dc.contributor.alternativeNameChoi, A Ra-
dc.contributor.alternativeNameKim, Ji Eun-
dc.contributor.alternativeNamePark, Se Woo-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorLee, Hyuk-
dc.contributor.affiliatedAuthorLee, Hyun Jik-
dc.contributor.affiliatedAuthorChong, Hyon Su-
dc.contributor.affiliatedAuthorChoi, A Ra-
dc.contributor.affiliatedAuthorPark, Se Woo-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.contributor.affiliatedAuthorKim, Ji Eun-
dc.rights.accessRightsnot free-
dc.citation.volume38-
dc.citation.number6-
dc.citation.startPage619-
dc.citation.endPage627-
dc.identifier.bibliographicCitationAlimentary Pharmacology and Therapeutics, Vol.38(6) : 619-627, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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