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Two Cases of Refractory Thrombocytopenia in Systemic Lupus Erythematosus that Responded to Intravenous Low-Dose Cyclophosphamide

Authors
 Hee-Jin Park  ;  Mi-il Kang  ;  Yoon Kang  ;  Soo-jin Chung  ;  Sang-Won Lee  ;  Yong-Beom Park  ;  Soo-Kon Lee 
Citation
 Journal of Korean Medical Science, Vol.28(3) : 472-475, 2013 
Journal Title
 Journal of Korean Medical Science 
ISSN
 1011-8934 
Issue Date
2013
Abstract
Treatment of thrombocytopenia in systemic lupus erythematosus (SLE) is considered in cases of current bleeding, severe bruising, or a platelet count below 50,000/µL. Corticosteroid is the first choice of medication for inducing remission, and immunosuppressive agents can be added when thrombocytopenia is refractory to corticosteroid or recurs despite it. We presented two SLE patients with thrombocytopenia who successfully induced remission after intravenous administration of low-dose cyclophosphamide (CYC) (500 mg fixed dose, biweekly for 3 months), followed by azathioprine (AZA) or mycophenolate mofetil (MMF). Both patients developed severe thrombocytopenia in SLE that did not respond to pulsed methylprednisolone therapy, and started the intravenous low-dose CYC therapy. In case 1, the platelet count increased to 50,000/µL after the first CYC infusion, and remission was maintained with low dose prednisolone and AZA. The case 2 achieved remission after three cycles of CYC, and the remission continued with low dose prednisolone and MMF.
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DOI
10.3346/jkms.2013.28.3.472
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강미일(Kang, Mi Il)
강윤(Kang, Yoon)
박용범(Park, Yong Beom)
박희진(Park, Hee Jin)
이상원(Lee, Sang Won)
이수곤(Lee, Soo Kon)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87540
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