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Two Cases of Refractory Thrombocytopenia in Systemic Lupus Erythematosus that Responded to Intravenous Low-Dose Cyclophosphamide

DC FieldValueLanguage
dc.contributor.author강미일-
dc.contributor.author강윤-
dc.contributor.author박용범-
dc.contributor.author박희진-
dc.contributor.author이상원-
dc.contributor.author이수곤-
dc.date.accessioned2014-12-18T09:06:14Z-
dc.date.available2014-12-18T09:06:14Z-
dc.date.issued2013-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/87540-
dc.description.abstractTreatment of thrombocytopenia in systemic lupus erythematosus (SLE) is considered in cases of current bleeding, severe bruising, or a platelet count below 50,000/µL. Corticosteroid is the first choice of medication for inducing remission, and immunosuppressive agents can be added when thrombocytopenia is refractory to corticosteroid or recurs despite it. We presented two SLE patients with thrombocytopenia who successfully induced remission after intravenous administration of low-dose cyclophosphamide (CYC) (500 mg fixed dose, biweekly for 3 months), followed by azathioprine (AZA) or mycophenolate mofetil (MMF). Both patients developed severe thrombocytopenia in SLE that did not respond to pulsed methylprednisolone therapy, and started the intravenous low-dose CYC therapy. In case 1, the platelet count increased to 50,000/µL after the first CYC infusion, and remission was maintained with low dose prednisolone and AZA. The case 2 achieved remission after three cycles of CYC, and the remission continued with low dose prednisolone and MMF.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfJournal of Korean Medical Science-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAzathioprine/therapeutic use-
dc.subject.MESHBone Marrow/pathology-
dc.subject.MESHCyclophosphamide/therapeutic use*-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/therapeutic use*-
dc.subject.MESHInfusions, Intravenous-
dc.subject.MESHLupus Erythematosus, Systemic/complications-
dc.subject.MESHLupus Erythematosus, Systemic/diagnosis*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMycophenolic Acid/analogs & derivatives-
dc.subject.MESHMycophenolic Acid/therapeutic use-
dc.subject.MESHPlatelet Count-
dc.subject.MESHThrombocytopenia/diagnosis*-
dc.subject.MESHThrombocytopenia/drug therapy*-
dc.subject.MESHThrombocytopenia/etiology-
dc.subject.MESHYoung Adult-
dc.titleTwo Cases of Refractory Thrombocytopenia in Systemic Lupus Erythematosus that Responded to Intravenous Low-Dose Cyclophosphamide-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHee-Jin Park-
dc.contributor.googleauthorMi-il Kang-
dc.contributor.googleauthorYoon Kang-
dc.contributor.googleauthorSoo-jin Chung-
dc.contributor.googleauthorSang-Won Lee-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorSoo-Kon Lee-
dc.identifier.doi10.3346/jkms.2013.28.3.472-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00022-
dc.contributor.localIdA00065-
dc.contributor.localIdA01579-
dc.contributor.localIdA01778-
dc.contributor.localIdA02889-
dc.contributor.localIdA03638-
dc.contributor.localIdA02824-
dc.relation.journalcodeJ01517-
dc.identifier.pmid23487584-
dc.subject.keywordCyclophosphamide-
dc.subject.keywordSystemic Lupus Erythematosus-
dc.subject.keywordThrombocytopenia-
dc.contributor.alternativeNameKang, Mi Il-
dc.contributor.alternativeNameKang, Yoon-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNamePark, Hee Jin-
dc.contributor.alternativeNameLee, Sang Won-
dc.contributor.alternativeNameLee, Soo Kon-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.affiliatedAuthorKang, Mi Il-
dc.contributor.affiliatedAuthorKang, Yoon-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorPark, Hee Jin-
dc.contributor.affiliatedAuthorLee, Soo Kon-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorLee, Sang Won-
dc.rights.accessRightsfree-
dc.citation.volume28-
dc.citation.number3-
dc.citation.startPage472-
dc.citation.endPage475-
dc.identifier.bibliographicCitationJournal of Korean Medical Science, Vol.28(3) : 472-475, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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